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Title

Prediction of Mortality Incidence in Patients with Chronic Kidney Disease Based on Influential Prognostic Factors with Competing Risks Approach

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Abstract

 Background: Chronic Kidney Disease (CKD) is a disease in which the kidney’ s functionality declines gradually. The aim of this study was to identify significant laboratory prognostic factors on death due to CKD in a clinical complex. Materials and Methods: A retrospective study including 109 patients with the end-stage renal disease treated at Iran Helal pharmaceutical and the clinical complex was conducted between 2014-2018. The survival time was set as the time interval between starting dialysis until death due to CKD. Also, the transplantation was considered as competing risk, which was occurred for a few patients. A three-parameter Gompertz model was used that considers both the event of interest and the competing event simultaneously. Results: Death due to CKD occurred in 29 (26. 6%) of the patients and 19(17. 4%) with transplantation. Serum uric acid was a significant prognostic factor that decreased the hazard of mortality by 21%. Serum phosphorus and age by increasing the risk of death, were poor prognoses for the event of interest. Serum uric acid and phosphorus 6. 9-9. 9 (mg/dl) were associated with 72% and 4. 05fold increased hazard of transplant, respectively. The 4-year cumulative incidence of death and transplant was 48. 4% and 29. 2%, respectively. Conclusion: We have deduced that high serum phosphorus levels and increased levels of age were associated with worse outcomes. High serum uric acid level was related to better survival, which could be explained by having a better protein-rich diet alongside the high albumin level.

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    APA: Copy

    Saeedi, Anahita, BAGHESTANI, AHMADREZA, HASHEMI NAZARI, SEYED SAEED, Minoo, Farzanehsadat, Mohseni, Navid, & ESFAHANI, ZAHRA. (2020). Prediction of Mortality Incidence in Patients with Chronic Kidney Disease Based on Influential Prognostic Factors with Competing Risks Approach. GALEN MEDICAL JOURNAL, 9(1), 0-0. SID. https://sid.ir/paper/784304/en

    Vancouver: Copy

    Saeedi Anahita, BAGHESTANI AHMADREZA, HASHEMI NAZARI SEYED SAEED, Minoo Farzanehsadat, Mohseni Navid, ESFAHANI ZAHRA. Prediction of Mortality Incidence in Patients with Chronic Kidney Disease Based on Influential Prognostic Factors with Competing Risks Approach. GALEN MEDICAL JOURNAL[Internet]. 2020;9(1):0-0. Available from: https://sid.ir/paper/784304/en

    IEEE: Copy

    Anahita Saeedi, AHMADREZA BAGHESTANI, SEYED SAEED HASHEMI NAZARI, Farzanehsadat Minoo, Navid Mohseni, and ZAHRA ESFAHANI, “Prediction of Mortality Incidence in Patients with Chronic Kidney Disease Based on Influential Prognostic Factors with Competing Risks Approach,” GALEN MEDICAL JOURNAL, vol. 9, no. 1, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/784304/en

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