Compound-Protein Interaction Analysis in Condition Following Cardiac Arrest

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ZAMANIAN AZODI MONA; REZAEI TAVIRANI MOSTAFA; REZAEI TAVIRANI MAJID

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Journal Paper

Paper Information

Journal: Galen Medical Journal Year:2018 | Volume:7 | Issue:1 Page(s): 0-0

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Title

Compound-Protein Interaction Analysis in Condition Following Cardiac Arrest

Author(s)

ZAMANIAN AZODI MONA | REZAEI TAVIRANI MOSTAFA | REZAEI TAVIRANI MAJID | Issue Writer Certificate

Keywords

Heart Arrest

Protein Interaction Maps

Biomarkers

Transcriptome

Abstract

Background: Cardiac arrest (CA) and differentially expressed genes (DEGs) relative to postCA have attracted the attention of scientist to prevent damages, which threaten patients. In the present study, metabolites relevant to DEGs of post-CA condition investigated via protein-compound interaction to understand the pathological mechanisms in the human body. Materials and Methods: STITCH plug-in integrated into Cytoscape V. 3. 6. 1 was used to detect the most significant interacting compounds relative to DEGs of pig’ s brain after 5 minutes’ CA. The genes were obtained from the Gene Expression Omnibus database. The identified elements were considered for further evaluation and validation by literature survey. Result: Findings indicate that biochemical compounds including magnesium, calcium, glucose, glycerol, hydrogen, chloride, sulfate, and estradiol interact with DEGs in the two up-and down-regulated networks. Conclusion: The compounds interacting with DEGs are suitable subjects to analysis for re-regulation of the body after CA.

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APA: Copy

ZAMANIAN AZODI, MONA, REZAEI TAVIRANI, MOSTAFA, & REZAEI TAVIRANI, MAJID. (2018). Compound-Protein Interaction Analysis in Condition Following Cardiac Arrest. GALEN MEDICAL JOURNAL, 7(1), 0-0. SID. https://sid.ir/paper/784630/en

Vancouver: Copy

ZAMANIAN AZODI MONA, REZAEI TAVIRANI MOSTAFA, REZAEI TAVIRANI MAJID. Compound-Protein Interaction Analysis in Condition Following Cardiac Arrest. GALEN MEDICAL JOURNAL[Internet]. 2018;7(1):0-0. Available from: https://sid.ir/paper/784630/en

IEEE: Copy

MONA ZAMANIAN AZODI, MOSTAFA REZAEI TAVIRANI, and MAJID REZAEI TAVIRANI, “Compound-Protein Interaction Analysis in Condition Following Cardiac Arrest,” GALEN MEDICAL JOURNAL, vol. 7, no. 1, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/784630/en

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