PREVALENCE OF HEMOGLOBINOPATHIES IN SISTAN AND BALOUCHISTAN PROVINCE IN THE SOUTHEAST OF IRAN

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MIRI MOGHADDAM E.; ESHGHI P.; SANEI MOGHADDAM E.; HASHEMI S.M.

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Journal: The Scientific Journal of Iranian Blood Transfusion Year:2013 | Volume:9 | Issue:4 (37) Page(s): 406-413

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Title

PREVALENCE OF HEMOGLOBINOPATHIES IN SISTAN AND BALOUCHISTAN PROVINCE IN THE SOUTHEAST OF IRAN

Author(s)

MIRI MOGHADDAM E. | ESHGHI P. | SANEI MOGHADDAM E. | HASHEMI S.M. | Issue Writer Certificate

Keywords

HEMOGLOBINOPATHIESQ3

THALASSEMIAQ3

MARRIAGEQ3

IRANQ3

Abstract

Background and Objectives: HEMOGLOBINOPATHIES are the most common single-gene disorders in IRAN. Sistan and Balouchistan has 2300 hemoglobinopathy patients who judiciously receive blood in the southeast of IRAN. In this study, the prevalence rate of HEMOGLOBINOPATHIES was evaluated in the province.Materials and Methods: This descriptive analytical study was performed on 2129 people at the age range of 5-10 years who were selected by multistage cluster sampling method. The number of samples in each city was proportional to its population size. Hematologic parameters were evaluated by automated cell counter on EDTA whole blood, hemoglobin A2 (HbA2) was determined by column chromatography, and hemoglobins were separated on Acetate Cellulose at pH=8.6. The samples with abnormal hemoglobins underwent electrophoresis at pH=6.1.Results: The results indicated 9.7% affected with minor THALASSEMIA, with the frequency being variable between 6.2% in north cities to 12.9% in south cities of the province. A total of 0.9, 1.7 and 0.1% were heterozygous for hemoglobin S, D, and C, respectively. HbA2 level of 72.4% of heterozygous HEMOGLOBINOPATHIES was estimated to be within the range of healthy individuals.Conclusions: The prevalence rate of b-thalassemia gene in the southern region of the province was higher than the average national rate. Current pre-marriage screening protocol is not able to identify all HEMOGLOBINOPATHIES in heterozygous cases. It is recommended where HEMOGLOBINOPATHIES are common, hemoglobin S detection be included in the screening program.

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APA: Copy

MIRI MOGHADDAM, E., ESHGHI, P., SANEI MOGHADDAM, E., & HASHEMI, S.M.. (2013). PREVALENCE OF HEMOGLOBINOPATHIES IN SISTAN AND BALOUCHISTAN PROVINCE IN THE SOUTHEAST OF IRAN. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 9(4 (37)), 406-413. SID. https://sid.ir/paper/78478/en

Vancouver: Copy

MIRI MOGHADDAM E., ESHGHI P., SANEI MOGHADDAM E., HASHEMI S.M.. PREVALENCE OF HEMOGLOBINOPATHIES IN SISTAN AND BALOUCHISTAN PROVINCE IN THE SOUTHEAST OF IRAN. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)[Internet]. 2013;9(4 (37)):406-413. Available from: https://sid.ir/paper/78478/en

IEEE: Copy

E. MIRI MOGHADDAM, P. ESHGHI, E. SANEI MOGHADDAM, and S.M. HASHEMI, “PREVALENCE OF HEMOGLOBINOPATHIES IN SISTAN AND BALOUCHISTAN PROVINCE IN THE SOUTHEAST OF IRAN,” THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), vol. 9, no. 4 (37), pp. 406–413, 2013, [Online]. Available: https://sid.ir/paper/78478/en

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