IN VITRO EVALUATION OF P-SELECTIN EXPRESSION OF PLATELET AND PLATELET AGGREGATION IN STORED PLATELET CONCENTRATES

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SADRI AZADEH; GHARAH BAGHIAN A.; VAELI SH.; KARBASIZADEH M.; GHALEDI ZH.; AGHAEIPOUR M.; SHASHANI T.; TABATABAEIAN A.A.S.; KAMI F.; AHMADINEZHAD MINOU; ASGARIPOUR F.

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Journal: The Scientific Journal of Iranian Blood Transfusion Year:2007 | Volume:4 | Issue:3 (15) Page(s): 205-213

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Title

IN VITRO EVALUATION OF P-SELECTIN EXPRESSION OF PLATELET AND PLATELET AGGREGATION IN STORED PLATELET CONCENTRATES

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Keywords

PLATELETQ3

P-SELECTINQ3

FLOWCYTOMETERYQ2

PLATELET AGGREGATIONQ3

Abstract

Background and Objectives: PLATELETs have a major role in haemostasis. PLATELET concentrates are used in thrombocytopeny and PLATELET dysfunction disorders. Due to recent studies reporting loss of in vivo function of PLATELETs in PLATELET concentrate units, we determined the level of surface expression of PSelectin, conducted PLATELET aggregation tests and pH measurment to evaluate PLATELET activation during storage.Materials and Methods: In a cross-sectional study, 100 PLATELET concentrate units prepared by PRP method were evaluated. 34, 33 and 33 units were taken from the first, second, and third day of storage respectively. For each PLATELET concentrate unit, pH, CD62P-Selectin and PLATELET aggregation tests with Arashidonic acid and Ristocetin agonists were conducted.Results: Expression of P-SELECTIN in third day was significantly higher than first day (p<0.05). PLATELET aggregation tests showed significant decrease in third day compared to first day (p<0.05). pH in third day was significantly higher than first day (p<0.05).Conclusions: The present study shows that activated PLATELETs during 3 days of storage have increased PSelectin on their surface. Therefore, the P-SELECTIN expression can be used as an in vivo marker for PLATELET activation function.

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APA: Copy

SADRI, AZADEH, GHARAH BAGHIAN, A., VAELI, SH., KARBASIZADEH, M., GHALEDI, ZH., AGHAEIPOUR, M., SHASHANI, T., TABATABAEIAN, A.A.S., KAMI, F., AHMADINEZHAD, MINOU, & ASGARIPOUR, F.. (2007). IN VITRO EVALUATION OF P-SELECTIN EXPRESSION OF PLATELET AND PLATELET AGGREGATION IN STORED PLATELET CONCENTRATES. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 4(3 (15)), 205-213. SID. https://sid.ir/paper/78489/en

Vancouver: Copy

SADRI AZADEH, GHARAH BAGHIAN A., VAELI SH., KARBASIZADEH M., GHALEDI ZH., AGHAEIPOUR M., SHASHANI T., TABATABAEIAN A.A.S., KAMI F., AHMADINEZHAD MINOU, ASGARIPOUR F.. IN VITRO EVALUATION OF P-SELECTIN EXPRESSION OF PLATELET AND PLATELET AGGREGATION IN STORED PLATELET CONCENTRATES. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)[Internet]. 2007;4(3 (15)):205-213. Available from: https://sid.ir/paper/78489/en

IEEE: Copy

AZADEH SADRI, A. GHARAH BAGHIAN, SH. VAELI, M. KARBASIZADEH, ZH. GHALEDI, M. AGHAEIPOUR, T. SHASHANI, A.A.S. TABATABAEIAN, F. KAMI, MINOU AHMADINEZHAD, and F. ASGARIPOUR, “IN VITRO EVALUATION OF P-SELECTIN EXPRESSION OF PLATELET AND PLATELET AGGREGATION IN STORED PLATELET CONCENTRATES,” THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), vol. 4, no. 3 (15), pp. 205–213, 2007, [Online]. Available: https://sid.ir/paper/78489/en

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