INVESTIGATION OF G2677T/A POLYMORPHISM IN MDR1 GENE OF CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA

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MOKHBERIAN N.; MAHJOUBI F.; POURAHMAD R.

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Journal: THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON) Year:2014 | Volume:11 | Issue:2 Page(s): 103-109

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Title

INVESTIGATION OF G2677T/A POLYMORPHISM IN MDR1 GENE OF CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA

Author(s)

MOKHBERIAN N. | MAHJOUBI F. | POURAHMAD R. | Issue Writer Certificate

Keywords

ACUTE LYMPHOBLASTIC LEUKEMIAQ2

DRUG RESISTANCEQ2

MDR1 PROTEINQ2

Abstract

Background and Objectives: The important reason of DRUG RESISTANCE is ATP dependent pumps such as MDR1 that extrudes drugs from the cell. MDR1 is highly polymorphic. It seems that polymorphisms influence the gene expression and response to treatment. The aim of this study was to investigate G2677T/A polymorphism of the MDR1 gene and its association with the response of treatment in childhood ACUTE LYMPHOBLASTIC LEUKEMIA.Materials and Methods: In this descriptive study, G2677T/A polymorphism of MDR1 was investigated in 44 children with ACUTE LYMPHOBLASTIC LEUKEMIA and 40 healthy individuals by the ARMS-PCR technique. The association of this polymorphism with response to treatment was also investigated.Results: In the patient group, the frequencies of genotypes were 36.4% for TT, 41% for GT, 13.6% for GG, 4.5% for AG, 2.25% for AT and 2.25 % for AA whereas in the control group the frequencies were 35%, 37.5%, 10%, 7.5%, 5%, and 5% for TT, GT, GG, AG, AT, and AA, respectively. There was no significant difference in the frequencies of G2677T/A polymorphism between patients and the healthy group. Neither was there any significant difference between the frequency rates of G2677T/A polymorphism of MDR1 in the responder and the non responder.Conclusions: It seems that there is no correlation between G2677T/A polymorphism of MDR1 gene and response to treatment. So the role of G2677T/A polymorphism in the gene expression of MDR1 in childhood ACUTE LYMPHOBLASTIC LEUKEMIA and response to treatment is still controversial.

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APA: Copy

MOKHBERIAN, N., MAHJOUBI, F., & POURAHMAD, R.. (2014). INVESTIGATION OF G2677T/A POLYMORPHISM IN MDR1 GENE OF CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 11(2), 103-109. SID. https://sid.ir/paper/78604/en

Vancouver: Copy

MOKHBERIAN N., MAHJOUBI F., POURAHMAD R.. INVESTIGATION OF G2677T/A POLYMORPHISM IN MDR1 GENE OF CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)[Internet]. 2014;11(2):103-109. Available from: https://sid.ir/paper/78604/en

IEEE: Copy

N. MOKHBERIAN, F. MAHJOUBI, and R. POURAHMAD, “INVESTIGATION OF G2677T/A POLYMORPHISM IN MDR1 GENE OF CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA,” THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), vol. 11, no. 2, pp. 103–109, 2014, [Online]. Available: https://sid.ir/paper/78604/en

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