EFFECTS OF CHIMERISM ON GRAFT-VERSUS-HOST DISEASE, DISEASE RECURRENCE AND SURVIVAL AFTER HLA-IDENTICAL MARROW TRANSPLANTATION IN IRAN

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GHAFFARI H.; ALI MOGHADAM K.; FOROUGHIFAR N.; CHAHARDOULI B.; SANAAT Z.; BAHAR B.; MOUSAVI A.; IRAVANI M.; GHAVAMZADEH ARDESHIR

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Journal: THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON) Year:2005 | Volume:2 | Issue:5 Page(s): 139-144

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Title

EFFECTS OF CHIMERISM ON GRAFT-VERSUS-HOST DISEASE, DISEASE RECURRENCE AND SURVIVAL AFTER HLA-IDENTICAL MARROW TRANSPLANTATION IN IRAN

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ALLOGENICQ4

BONE MARROW TRANSPLANTATIONQ4

CHIMERISMQ4

PCRQ4

Abstract

Background and Objectives The co-existence of recipient’s and donors hematopoietic systems after allogeneic marrow transplantation is called mixed CHIMERISM. CHIMERISM analysis provides a national method of assessing the ability of different conditioning regimens, graft-versus-host disease (GVHD), prophylactic regimens, and cellular therapy to promote engraftment.Materials and Methods The association of mixed CHIMERISM with acute graft-versus-host disease (GVHD), disease recurrence, survival, and relapse free survival was investigated in 91 patients 12 and 79 of whom underwent either bone or peripheral blood HLA-identical marrow transplantation respectively. CHIMERISM was assessed using multiplex amplification of shorty tandem repeats (STR-PCR). Cases included thalassemics (19 subjects), AML (29), ALL (20), CML (18) and others (5). Median age was 21 (age range of 3-50). There were 38 females (41.8%) and 53 males (58.2%). Conditioning was busulfan plus cyclophosphamide in 34 patients, busulfan plus fludarabin in 51 patients and busulfan plus fludarabin plus anti-thymocyte globulin in 6 patients. Median time of follow up was 13 months. Data was analyzed using SPSS statistical software.Results On day 30 after transplantation, mixed CHIMERISM (MC) was observed in 15 patients (16.5%), complete donor CHIMERISM (CC) in 72 patients (79%), and no CHIMERISM in 4 patients. The incidence of acute GVHD was significantly lower in mixed chimeras than in complete chimeras (p=0.01) but there was no significant difference in acute GVHD grade (I, II vs. III, IV) between two groups. The incidence of relapse and overall survival were 17.6% and 88.9% respectively showing no significant difference between MC and CC. Relapse free survival was 80.2% and not significantly different between two groups.ConclusionsDespite some previous reports, we found no significant difference in survival and relapse rate between MC and CC.

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APA: Copy

GHAFFARI, H., ALI MOGHADAM, K., FOROUGHIFAR, N., CHAHARDOULI, B., SANAAT, Z., BAHAR, B., MOUSAVI, A., IRAVANI, M., & GHAVAMZADEH, ARDESHIR. (2005). EFFECTS OF CHIMERISM ON GRAFT-VERSUS-HOST DISEASE, DISEASE RECURRENCE AND SURVIVAL AFTER HLA-IDENTICAL MARROW TRANSPLANTATION IN IRAN. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 2(5), 139-144. SID. https://sid.ir/paper/78715/en

Vancouver: Copy

GHAFFARI H., ALI MOGHADAM K., FOROUGHIFAR N., CHAHARDOULI B., SANAAT Z., BAHAR B., MOUSAVI A., IRAVANI M., GHAVAMZADEH ARDESHIR. EFFECTS OF CHIMERISM ON GRAFT-VERSUS-HOST DISEASE, DISEASE RECURRENCE AND SURVIVAL AFTER HLA-IDENTICAL MARROW TRANSPLANTATION IN IRAN. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)[Internet]. 2005;2(5):139-144. Available from: https://sid.ir/paper/78715/en

IEEE: Copy

H. GHAFFARI, K. ALI MOGHADAM, N. FOROUGHIFAR, B. CHAHARDOULI, Z. SANAAT, B. BAHAR, A. MOUSAVI, M. IRAVANI, and ARDESHIR GHAVAMZADEH, “EFFECTS OF CHIMERISM ON GRAFT-VERSUS-HOST DISEASE, DISEASE RECURRENCE AND SURVIVAL AFTER HLA-IDENTICAL MARROW TRANSPLANTATION IN IRAN,” THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), vol. 2, no. 5, pp. 139–144, 2005, [Online]. Available: https://sid.ir/paper/78715/en

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