PROTECTIVE EFFECT OF VITAMIN E ON THE PARA-NONYLPHENOL INDUCED-TESTICULAR TOXICITY IN ADULT RATS: A STEREOLOGICAL STUDY

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SOLEIMANI MEHRANJANI M.; NADERI NOREINI S.

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Title

PROTECTIVE EFFECT OF VITAMIN E ON THE PARA-NONYLPHENOL INDUCED-TESTICULAR TOXICITY IN ADULT RATS: A STEREOLOGICAL STUDY

Author(s)

SOLEIMANI MEHRANJANI M. | NADERI NOREINI S. | Issue Writer Certificate

Keywords

TESTISQ2

SEMINIFEROUS TUBULEQ2

PARA-NONYLPHENOLQ2

VITAMIN EQ2

STEREOLOGYQ3

RATQ2

Abstract

Background and Objective: Para-nonylphen as an environmental pollutant has weak estrogenic activity and causes oxidative stress in different organs including TESTIS. This study was done to determine the protective effect of VITAMIN E on the PARA-NONYLPHENOL induced-testicular toxicity in adult RATs.Methods: In this experimental study, 24 Wistar RATs were randomly allocated into four groups including control, VITAMIN E (100 mg/kg/day, orally), PARA-NONYLPHENOL (250 mg/kg/day, orally) and finally paranonylphenol (250 mg/kg/day, orally) plus VITAMIN E (100 mg/kg/day, orally). After 56 days of treatment, removal of the right TESTIS, tissue processing and staining with Heidenhain’s Azan, the morphometric parameters of testicular tissue was evaluated using stereological method.Results: The mean volume of SEMINIFEROUS TUBULEs, height of the germinal epithelium, SEMINIFEROUS TUBULEs diameter, thickness of the basement membrane, number of spermatocyte, spermatid and sertoli cells significantly reduced in PARA-NONYLPHENOL group compared to the controls (P<0.05). These parameters were significantly increased in the PARA-NONYLPHENOL plus VITAMIN E group compared to PARA-NONYLPHENOL group (P<0.05). In the histopathological examination, atrophy of SEMINIFEROUS TUBULEs, germinal epithelium vacuolation and epithelial disarrangement were observed in PARA-NONYLPHENOL group. Histopathological alterations reduced in PARA-NONYLPHENOL plus VITAMIN E group compared to PARA-NONYLPHENOL group.Conclusion: Co-administration of VITAMIN E with PARA-NONYLPHENOL can prevent the adverse effects of PARA-NONYLPHENOL on the testicular tissue in adult RATs.

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APA: Copy

SOLEIMANI MEHRANJANI, M., & NADERI NOREINI, S.. (2014). PROTECTIVE EFFECT OF VITAMIN E ON THE PARA-NONYLPHENOL INDUCED-TESTICULAR TOXICITY IN ADULT RATS: A STEREOLOGICAL STUDY. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 16(3 (51)), 31-39. SID. https://sid.ir/paper/78801/en

Vancouver: Copy

SOLEIMANI MEHRANJANI M., NADERI NOREINI S.. PROTECTIVE EFFECT OF VITAMIN E ON THE PARA-NONYLPHENOL INDUCED-TESTICULAR TOXICITY IN ADULT RATS: A STEREOLOGICAL STUDY. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;16(3 (51)):31-39. Available from: https://sid.ir/paper/78801/en

IEEE: Copy

M. SOLEIMANI MEHRANJANI, and S. NADERI NOREINI, “PROTECTIVE EFFECT OF VITAMIN E ON THE PARA-NONYLPHENOL INDUCED-TESTICULAR TOXICITY IN ADULT RATS: A STEREOLOGICAL STUDY,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 16, no. 3 (51), pp. 31–39, 2014, [Online]. Available: https://sid.ir/paper/78801/en

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