THE COMPARISON THERAPEUTIC EFFECT OF NALTREXONE AND FLOUXETINE ON OBSESSIVE-COMPULSIVE DISORDER (O.C.D) A CLINICAL TRIAL STUDY

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MASOUDZADEH A.; MAHMOUDI MITRA; SALJOUGHIAN A.

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Journal: Journal of Gorgan University of Medical Sciences Year:2008 | Volume:9 | Issue:4 (24) Page(s): 18-24

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Title

THE COMPARISON THERAPEUTIC EFFECT OF NALTREXONE AND FLOUXETINE ON OBSESSIVE-COMPULSIVE DISORDER (O.C.D) A CLINICAL TRIAL STUDY

Author(s)

MASOUDZADEH A. | MAHMOUDI MITRA | SALJOUGHIAN A. | Issue Writer Certificate

Keywords

O.C.DQ3

NALTREXONEQ3

FLOUXETINEQ3

YALE-BROWN SCALE OF O.C.D (YBOCS)Q3

Abstract

Background & Objective: In spit of high prevalancey of the Obsessive-Compulsive Disorder in anxity diseases. It shows the least therapeutic responses. This study was done to determine the comparison of therapeutic effect of NALTREXONE and FLOUXETINE on Obsessive-Compulsive Disorder (O.C.D).Materials & Methods: This double-blind clinical trial study was done on 30 patients aged 18 to 60 years referring to the clinics of psychiatry at Zareh hospital in Sari-Iran during 2006. Patients in three groups, treated with FLOUXETINE 53.9mg/d (group A); NALTREXONE 64.4mg/d (group B) & Pelacebo (group C) in the same shape capsula respectively. The severity of O.C.D was evaluated at 4 steps with Yale-Brown scale. The obtained data were analyzed using parametric & nonparametric tests.Results: NALTREXONE reduced the severity of O.C.D symptoms significantly (45.01%) at the end of week 8th (p<0.05). Same result (45.81%) was observed using FLOUXETINE (P=0.79). The rate of efficaey in both drugs significantly was higher than pelacebo (P<0.05).Conclusion: This study showed than, NALTREXONE has the same level of reducting symptome of OCD but even with faster therapeutic effect than Flouxetin.

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APA: Copy

MASOUDZADEH, A., MAHMOUDI, MITRA, & SALJOUGHIAN, A.. (2008). THE COMPARISON THERAPEUTIC EFFECT OF NALTREXONE AND FLOUXETINE ON OBSESSIVE-COMPULSIVE DISORDER (O.C.D) A CLINICAL TRIAL STUDY. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 9(4 (24)), 18-24. SID. https://sid.ir/paper/78874/en

Vancouver: Copy

MASOUDZADEH A., MAHMOUDI MITRA, SALJOUGHIAN A.. THE COMPARISON THERAPEUTIC EFFECT OF NALTREXONE AND FLOUXETINE ON OBSESSIVE-COMPULSIVE DISORDER (O.C.D) A CLINICAL TRIAL STUDY. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2008;9(4 (24)):18-24. Available from: https://sid.ir/paper/78874/en

IEEE: Copy

A. MASOUDZADEH, MITRA MAHMOUDI, and A. SALJOUGHIAN, “THE COMPARISON THERAPEUTIC EFFECT OF NALTREXONE AND FLOUXETINE ON OBSESSIVE-COMPULSIVE DISORDER (O.C.D) A CLINICAL TRIAL STUDY,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 9, no. 4 (24), pp. 18–24, 2008, [Online]. Available: https://sid.ir/paper/78874/en

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