THE PROTECTIVE THERAPEUTIC EFFECT OF SILYMARIN IN ACUTE HEPATOTOXICITY OF CCL4 IN RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AYAT ELAHI HASAN; OMIDI ABAS ALI; KATEBI M.; SABAGH SAEIDEH; TAVASOLIAN H.; KHALIGHI M.R.; PARDAKHTI M.; SHARIAT ABAS

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES Year:2008 | Volume:9 | Issue:4 (24) Page(s): 11-17

Download Full-Text

Persian Verion

View:

1,330

Download:

Cites:

Information Journal Paper

Title

THE PROTECTIVE THERAPEUTIC EFFECT OF SILYMARIN IN ACUTE HEPATOTOXICITY OF CCL4 IN RATS

Author(s)

Keywords

SILYMARINQ3

CCL4Q2

HEPATOTOXICITYQ2

Abstract

Background & Objective: Tetra Carbon Cholride has been known as reference hepatotoxin because it can cause necrosis, fatty change, cirrhosis and cancer liver. SILYMARIN has hepatoprotective and anti hepatoxin effect. This study was done to determine the protective effect of SILYMARIN in acute HEPATOTOXICITY of CCL4 in rats. Materials & Methods: In this experimental study, we chose 25ml/kg dose of CCL4 (in mineral oil solvent) as an optimum dose. The hepatotoxic effects of intraperiotoneal injection of CCL4 for obtaining parameters of toxicity and therapeutic effects have been examined. According to enzymatic results (increase in ALT and AST) and histopathologic changes (grading the changes in liver including cytoplasmic granularity, cloudy swelling, necrosis and fatty change), the interval between prescribing SILYMARIN and sampling was determined. SILYMARIN as a suspension in propylene glycol CMC 2% (3/2 ratio) has been prescribed in 50, 200 and 800mg/kg doses and serum and liver samples were obtained. Negative control group received SILYMARIN vehicle in CCL4 solvent, drug control received 800 mg/kg of SILYMARIN in CCL4 solvent and positive control received SILYMARIN vehicle after injecting CCL4. Results: The results showed that prescribing 50mg/kg SILYMARIN one hour after injecting CCL4, in addition to inhibiting transaminase activity, prevents progress of liver injury up to 50% of positive control group. Cellular repair and regeneration are also enhanced, So the grade 3necrosis in positive control group is decreased to grade 0.5 in SILYMARIN gourp in 48 hours prescribing SILYMARIN (50mg/kg). Conclusion: This study showed that up to six hours after injecting CCL4 significantly prevents HEPATOTOXICITY, and cause acceleration in repair of liver injuries.

Cites

No record.

References

No record.

Cite

APA: Copy

AYAT ELAHI, HASAN, OMIDI, ABAS ALI, KATEBI, M., SABAGH, SAEIDEH, TAVASOLIAN, H., KHALIGHI, M.R., PARDAKHTI, M., & SHARIAT, ABAS. (2008). THE PROTECTIVE THERAPEUTIC EFFECT OF SILYMARIN IN ACUTE HEPATOTOXICITY OF CCL4 IN RATS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 9(4 (24)), 11-17. SID. https://sid.ir/paper/78882/en

Vancouver: Copy

AYAT ELAHI HASAN, OMIDI ABAS ALI, KATEBI M., SABAGH SAEIDEH, TAVASOLIAN H., KHALIGHI M.R., PARDAKHTI M., SHARIAT ABAS. THE PROTECTIVE THERAPEUTIC EFFECT OF SILYMARIN IN ACUTE HEPATOTOXICITY OF CCL4 IN RATS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2008;9(4 (24)):11-17. Available from: https://sid.ir/paper/78882/en

IEEE: Copy

HASAN AYAT ELAHI, ABAS ALI OMIDI, M. KATEBI, SAEIDEH SABAGH, H. TAVASOLIAN, M.R. KHALIGHI, M. PARDAKHTI, and ABAS SHARIAT, “THE PROTECTIVE THERAPEUTIC EFFECT OF SILYMARIN IN ACUTE HEPATOTOXICITY OF CCL4 IN RATS,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 9, no. 4 (24), pp. 11–17, 2008, [Online]. Available: https://sid.ir/paper/78882/en

Related Journal Papers