ADDITIVE EFFECTS OF TRANS-RESVERATROL AND IMIPRAMINE TO REDUCE DEPRESSIVE SYMPTOMS IN THE FORCED SWIMMING TEST IN MICE

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ATAEE R.; GITINAVARD A.H.; ATAIE A.; NOURIAN Y.; SHATERPOUR M.

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Journal: Journal of Gorgan University of Medical Sciences Year:2016 | Volume:18 | Issue:3 (59) Page(s): 40-44

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Title

ADDITIVE EFFECTS OF TRANS-RESVERATROL AND IMIPRAMINE TO REDUCE DEPRESSIVE SYMPTOMS IN THE FORCED SWIMMING TEST IN MICE

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Keywords

DEPRESSIONQ2

RESVERATROLQ1

IMIPRAMINEQ3

FORCED SWIMMING TESTQ1

MOUSEQ3

Abstract

Background and Objective: RESVERATROL is a phenolic herbal compound which has been proposed as antioxidant in combinational therapy of diabetes, cancer and some neurodegenerative diseases. This study was done to evaluate additive effect of trans-resveratrol and IMIPRAMINE to reduce depressive symptoms in the FORCED SWIMMING TEST in mice.Methods: In this experimental study, 56 Swiss Webster male mice were randomly allocated into 6 groups including negative control group (normal saline), positive control (imipramine (10 mg/kg/bw), experimental groups; trans RESVERATROL (10 mg/kg/bw), Imipiramine (10 mg/kg/bw) and mixtures (with ratio of 1: 1 of RESVERATROL with IMIPRAMINE (2.5 mg/kg/bw, 5 and 10 mg/kg/bw), intraperitoneally. The FORCED SWIMMING TEST has been done for all groups. Through swimming of animals in water, the immobilization times of animals as depressive symptom were recorded.Results: The immobilization times significantly reduced in animals which were received IMIPRAMINE 10 mg/kg/bw in compare to control group (P<0.05). The immobilization times of animals were received RESVERATROL injection 10 mg/kg/bw with IMIPRAMINE 10 mg/kg/bw was determined which it was significantly effective than IMIPRAMINE10 mg/kg/bw, alone (P<0.05). The antidepressant effectiveness of RESVERATROL injection 5 mg/kg/bw is similar to RESVERATROL (2.5 mg/kg/bw) with IMIPRAMINE (2.5mg/kg/bw).is similar to RESVERATROL (2.5 mg/kg) with IMIPRAMINE (2.5 mg/kg/bw) (P<0.05). Also, antidepressant effect of intraperitoneal administration of RESVERATROL 10 mg/kg was significantly more than IMIPRAMINE 10 mg/kg/bw (P<0.05).Conclusion: According to additive effect of IMIPRAMINE with RESVERATROL we can suggest RESVERATROL in combinations with other antidepressants to lower their doses and related side effects of chemical drugs.

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APA: Copy

ATAEE, R., GITINAVARD, A.H., ATAIE, A., NOURIAN, Y., & SHATERPOUR, M.. (2016). ADDITIVE EFFECTS OF TRANS-RESVERATROL AND IMIPRAMINE TO REDUCE DEPRESSIVE SYMPTOMS IN THE FORCED SWIMMING TEST IN MICE. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 18(3 (59)), 40-44. SID. https://sid.ir/paper/78890/en

Vancouver: Copy

ATAEE R., GITINAVARD A.H., ATAIE A., NOURIAN Y., SHATERPOUR M.. ADDITIVE EFFECTS OF TRANS-RESVERATROL AND IMIPRAMINE TO REDUCE DEPRESSIVE SYMPTOMS IN THE FORCED SWIMMING TEST IN MICE. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;18(3 (59)):40-44. Available from: https://sid.ir/paper/78890/en

IEEE: Copy

R. ATAEE, A.H. GITINAVARD, A. ATAIE, Y. NOURIAN, and M. SHATERPOUR, “ADDITIVE EFFECTS OF TRANS-RESVERATROL AND IMIPRAMINE TO REDUCE DEPRESSIVE SYMPTOMS IN THE FORCED SWIMMING TEST IN MICE,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 18, no. 3 (59), pp. 40–44, 2016, [Online]. Available: https://sid.ir/paper/78890/en

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