MODIFICATION OF NALOXONE-INDUCED WITHDRAWAL SIGNS BY ASCORBIC ACID IN MORPHINE-DEPENDENT GUINEA-PIGS

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FARZIN D.; ARJMAND A.; AGHABARARI F.

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Journal: JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES Year:2006 | Volume:8 | Issue:3 (19) Page(s): 8-15

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Title

MODIFICATION OF NALOXONE-INDUCED WITHDRAWAL SIGNS BY ASCORBIC ACID IN MORPHINE-DEPENDENT GUINEA-PIGS

Author(s)

FARZIN D. | ARJMAND A. | AGHABARARI F. | Issue Writer Certificate

Keywords

ASCORBIC ACIDQ3

WITHDRAWAL SYNDROMQ3

MORPHINEQ3

NALOXONEQ3

DOPAMINEQ3

GUINEAQ3

PIGSQ3

Abstract

Background & Objective: ASCORBIC ACID, an antioxidant vitamin, is found throughout the mammalian central nervous system. Although, the centeral role of ASCORBIC ACID is unclear, but there is good evidence that ASCORBIC ACID modulates opiate WITHDRAWAL SYNDROMe. This study was done to determine the effect of ASCORBIC ACID (AA.) on NALOXONE-induced withdrawal signs in MORPHINE-dependent GUINEA-pigs.Materials & Methods: In this experimental study, male GUINEA-pigs (300-400 g; 8-10 animals/group) were rendered dependent on MORPHINE by subcutaneous (s.c.) injections of MORPHINE sulfate 3 times a day for 3 days, and withdrawal signs were induced by intraperitoneal (i.p.) administration of NALOXONE (15 mg/kg) 2 h after the tenth injection of MORPHINE suifate on day 4; then animals were placed individually into a cylindrical glass (25 cm in diameter, 180 cm height) and the withdrawal signs were recorded over a 60-min period.Results: Chronic pretreatment of GUINEA-pigs with AA, 200 mg/kg, S.c.3 times daily for 3 days, reduced withdrawal jumping, digging, writhing, rearing, face washing, head and body shakes, penile licking and diarrhea. The mixed DOPAMINE D1/D2 receptor agonist apomorphine (0.5 mg/kg, s.c.) markedly antagonized the inhibitory effect of A.A. on the withdrawal signs.The effect of apomorphine was blocked by the DOPAMINE Dl receptor antagonist SCH23390 (0.5 and 1mg/kg, i.p.) but not by the DOPAMINE D2 receptor antagonist sulpiride (50 mg/kg, s.c.) nor the peripheral DOPAMINE receptor antagonist domperidone (1 mg/kg, s.c.).Conclusion: It is concluded that chronic administration of ASCORBIC ACID inhibits opiate withdrawal, via a central DOPAMINE D1 receptor mechanism.

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APA: Copy

FARZIN, D., ARJMAND, A., & AGHABARARI, F.. (2006). MODIFICATION OF NALOXONE-INDUCED WITHDRAWAL SIGNS BY ASCORBIC ACID IN MORPHINE-DEPENDENT GUINEA-PIGS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 8(3 (19)), 8-15. SID. https://sid.ir/paper/78937/en

Vancouver: Copy

FARZIN D., ARJMAND A., AGHABARARI F.. MODIFICATION OF NALOXONE-INDUCED WITHDRAWAL SIGNS BY ASCORBIC ACID IN MORPHINE-DEPENDENT GUINEA-PIGS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2006;8(3 (19)):8-15. Available from: https://sid.ir/paper/78937/en

IEEE: Copy

D. FARZIN, A. ARJMAND, and F. AGHABARARI, “MODIFICATION OF NALOXONE-INDUCED WITHDRAWAL SIGNS BY ASCORBIC ACID IN MORPHINE-DEPENDENT GUINEA-PIGS,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 8, no. 3 (19), pp. 8–15, 2006, [Online]. Available: https://sid.ir/paper/78937/en

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