EFFECT OF HYDRO ALCOHOLIC EXTRACT OF PLANTAGO MAJOR L. ON PENTILENTETRAZOL-INDUCED SEIZURES IN MALE MICE

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KAVYANIFARD S.; HEIDARIEH N.; JAMALO F.; ALINEJAD G.; ALINEJAD M.; MOHAMMAD EINI A.

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Journal: JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES Year:2016 | Volume:18 | Issue:2 (58) Page(s): 41-45

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Title

EFFECT OF HYDRO ALCOHOLIC EXTRACT OF PLANTAGO MAJOR L. ON PENTILENTETRAZOL-INDUCED SEIZURES IN MALE MICE

Author(s)

Keywords

PLANTAGO MAJOR LQ1

PENTYLENTETRAZOLEQ2

SEIZURE THRESHOLDQ3

MOUSEQ2

Abstract

Background and Objective: Epilepsy is a common neurological disorder. Plantago major (P. major) is used in traditional medicine due to flovonoids and vitamic C and antioxidant properties. This study was done to evaluate the hydro alcoholic extract of PLANTAGO MAJOR L. on pentilentetrazol-induced seizures in male mice.Methods: In this experimental study, 50 NMRI male mice randomly allocated into control and four experimental groups. Seizures in animals induced by 60 mg/kg/bw of pentilentetrazol (PTZ), interperitoneally. Animals in experimental groups were received 5, 10, 25 and 50 mg/kg/bw of hydro alcoholic extract of PLANTAGO MAJOR L. 30 min before each PTZ injection. The animals in control group were received saline, interperitoneally. After treatment, the behavior of animals during 20 minutes and mortality rate were recorded.Results: SEIZURE THRESHOLD of animals significantly increased in experimental groups which were received 50, 25, 10 mg/kg/bw of P. major extract in comparision with controls (P<0.05). Mortality rate of animals significantly reduced in experimental groups which were received 50, 25, 10 mg/kg/bw of P. major extract in comparision with controls (P<0.05).Conclusion: The hydro-alcoholic extract of PLANTAGO MAJOR L. reduces SEIZURE THRESHOLD in pentilentetrazol-induced seizures mice.

Cites

STUDY OF THE ANXIOLYTIC EFFECTS OF PLANTGO MAJOR L. AND POSSIBLE ROLE OF GABAERGIC SYSTEM IN THESE EFFECTS IN RATS

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APA: Copy

KAVYANIFARD, S., HEIDARIEH, N., JAMALO, F., ALINEJAD, G., ALINEJAD, M., & MOHAMMAD EINI, A.. (2016). EFFECT OF HYDRO ALCOHOLIC EXTRACT OF PLANTAGO MAJOR L. ON PENTILENTETRAZOL-INDUCED SEIZURES IN MALE MICE. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 18(2 (58)), 41-45. SID. https://sid.ir/paper/79002/en

Vancouver: Copy

KAVYANIFARD S., HEIDARIEH N., JAMALO F., ALINEJAD G., ALINEJAD M., MOHAMMAD EINI A.. EFFECT OF HYDRO ALCOHOLIC EXTRACT OF PLANTAGO MAJOR L. ON PENTILENTETRAZOL-INDUCED SEIZURES IN MALE MICE. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;18(2 (58)):41-45. Available from: https://sid.ir/paper/79002/en

IEEE: Copy

S. KAVYANIFARD, N. HEIDARIEH, F. JAMALO, G. ALINEJAD, M. ALINEJAD, and A. MOHAMMAD EINI, “EFFECT OF HYDRO ALCOHOLIC EXTRACT OF PLANTAGO MAJOR L. ON PENTILENTETRAZOL-INDUCED SEIZURES IN MALE MICE,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 18, no. 2 (58), pp. 41–45, 2016, [Online]. Available: https://sid.ir/paper/79002/en

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