RISK FACTORS IN CHILDHOOD LYMPHOBLASTIC LEUKEMIA IN SHIRAZ-IRAN (2009): AN EPIDEMILOGICAL STUDY

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HASSANZADE J.; MOHAMMADI R.; RAJAEEFARD A.R.

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Journal: Journal of Gorgan University of Medical Sciences Year:2013 | Volume:14 | Issue:4 (44) Page(s): 119-124

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Title

RISK FACTORS IN CHILDHOOD LYMPHOBLASTIC LEUKEMIA IN SHIRAZ-IRAN (2009): AN EPIDEMILOGICAL STUDY

Author(s)

HASSANZADE J. | MOHAMMADI R. | RAJAEEFARD A.R. | Issue Writer Certificate

Keywords

ACUTE LYMPHOBLASTIC LEUKEMIAQ3

FATHER OCCUPATIONQ4

BIRTH ORDERQ3

PETQ2

Abstract

Background and Objective: The etiology of childhood leukemia as the most common childhood malignancy remains largely unknown. This study was done to ascess the risk factors in childhood lymphoblastic leukemia in Shiraz-Iran.Materials and Methods: This case-control study was done on 141 children younger than 18 years suffering from ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) whome resided at Fars Province of Iran during 2009. Patients were individually matched with 141 controls in respect to age, sex and residential area. Variables included: maternal age, parental education, FATHER OCCUPATION, child birth weight and BIRTH ORDER, number of siblings, history of PET ownership including cat or dog, history of child day care attendance, history of leukemia in relatives, and history of mother diagnostic radiography during pregnancy. In order to evaluate the relationships between each variable and the risk of leukemia, odds ratio (OR) and 95% confidence interval (CI) were estimated using conditional logistic regression. Data were analyzed using SPSS-16 and Chi-Square test.Results: The agricultural occupation fathers in case and control were 17% and 5.7%, respectivley (P<0.01). The association between risk of childhood lymphoblastic leukemia with BIRTH ORDER³3 (OR=5.939, 95% CI: 2.646-13.331, P<0.01), PET ownership (dog or cat) (OR=2.582, 95% CI: 1.265-5.269, P<0.009) and history of leukemia in first and second degree relatives (OR=3.5, 95% CI: 1.252-10.633, P<0.027) was significant. No relationship was found between birth weight, day care attendance, history of miscarriage, number of siblings and history of mother diagnostic radiology tests with risk of ACUTE LYMPHOBLASTIC LEUKEMIA.Conclusion: This study showed that FATHER OCCUPATION, BIRTH ORDER, PET and history of leukemia in relation are risk factors of childhood ACUTE LYMPHOBLASTIC LEUKEMIA.

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APA: Copy

HASSANZADE, J., MOHAMMADI, R., & RAJAEEFARD, A.R.. (2013). RISK FACTORS IN CHILDHOOD LYMPHOBLASTIC LEUKEMIA IN SHIRAZ-IRAN (2009): AN EPIDEMILOGICAL STUDY. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 14(4 (44)), 119-124. SID. https://sid.ir/paper/79079/en

Vancouver: Copy

HASSANZADE J., MOHAMMADI R., RAJAEEFARD A.R.. RISK FACTORS IN CHILDHOOD LYMPHOBLASTIC LEUKEMIA IN SHIRAZ-IRAN (2009): AN EPIDEMILOGICAL STUDY. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2013;14(4 (44)):119-124. Available from: https://sid.ir/paper/79079/en

IEEE: Copy

J. HASSANZADE, R. MOHAMMADI, and A.R. RAJAEEFARD, “RISK FACTORS IN CHILDHOOD LYMPHOBLASTIC LEUKEMIA IN SHIRAZ-IRAN (2009): AN EPIDEMILOGICAL STUDY,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 14, no. 4 (44), pp. 119–124, 2013, [Online]. Available: https://sid.ir/paper/79079/en

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