PALMATINE HYDROCHLORIDE IMPROVES MOTOR DYSFUNCTION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

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AHOUEI M.; VAEZI GH.; KALALIAN MOGHADDAM H.

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Journal: Journal of Gorgan University of Medical Sciences Year:2014 | Volume:16 | Issue:1 (49) Page(s): 42-48

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Title

PALMATINE HYDROCHLORIDE IMPROVES MOTOR DYSFUNCTION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

Author(s)

AHOUEI M. | VAEZI GH. | KALALIAN MOGHADDAM H. | Issue Writer Certificate

Keywords

DIABETES MELLITUSQ2

PALMATINE HYDROCHLORIDEQ2

MOTOR DYSFUNCTIONSQ2

STREPTOZOTOCINQ2

RATQ2

Abstract

Background and Objective: Diabetes induces MOTOR DYSFUNCTIONS, Palmatine is an isoquinoline alkaloid, with anti-diabetic and antioxidant activities. This study was conducted to evaluate the effect of Palmatine on motor dysfunction in STZ-induced diabetic RATs.Materials and Methods: In this experimental study, 32 male wistar RATs were randomly allocated into control, Palmatine-treated non-diabetic, diabetic and Palmatine-treated diabetic groups. Diabetes was induced by STZ administration at the dose of 55 mg/kg/bw, intraperitoneally. PALMATINE HYDROCHLORIDE was administered subcutaneous at doses of 10 mg/kg/bw per day for a period of 6 weeks, one week after induction of diabetes. Blood glucose level was measured 1, 3, 5, 7 weeks after STZ injection. Locomotor activity tests including Y maze, grip-traction and inclined plane tests were performed to determining locomotor activity.Results: In Y maze test, the number of arms entered significantly increased in Palmatine-treated diabetic group compared to diabetic group (P<0.05). Grip traction and inclined plane tests significantly increased in Palmatine-treated diabetic group compared to diabetics animals (P<0.05).Conclusion: PALMATINE HYDROCHLORIDE administration for 6 weeks improves MOTOR DYSFUNCTIONS in STREPTOZOTOCIN-induced diabetic RATs.

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APA: Copy

AHOUEI, M., VAEZI, GH., & KALALIAN MOGHADDAM, H.. (2014). PALMATINE HYDROCHLORIDE IMPROVES MOTOR DYSFUNCTION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 16(1 (49)), 42-48. SID. https://sid.ir/paper/79114/en

Vancouver: Copy

AHOUEI M., VAEZI GH., KALALIAN MOGHADDAM H.. PALMATINE HYDROCHLORIDE IMPROVES MOTOR DYSFUNCTION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;16(1 (49)):42-48. Available from: https://sid.ir/paper/79114/en

IEEE: Copy

M. AHOUEI, GH. VAEZI, and H. KALALIAN MOGHADDAM, “PALMATINE HYDROCHLORIDE IMPROVES MOTOR DYSFUNCTION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 16, no. 1 (49), pp. 42–48, 2014, [Online]. Available: https://sid.ir/paper/79114/en

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