EFFECT OF EXERCISE PROGRAM AND CURCUMIN SUPPLEMENTATION ON SERUM LEVEL OF IMMUNOGLOBULIN A IN RATS EXPOSED TO LEAD ACETATE

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MIRDAR SH.; RAMEZANNEZHAD A.; ARZANI A.; ALINEZHAD M.; HAJIZADE A.

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Journal: Journal of Gorgan University of Medical Sciences Year:2014 | Volume:16 | Issue:1 (49) Page(s): 49-54

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Title

EFFECT OF EXERCISE PROGRAM AND CURCUMIN SUPPLEMENTATION ON SERUM LEVEL OF IMMUNOGLOBULIN A IN RATS EXPOSED TO LEAD ACETATE

Author(s)

Keywords

LEAD ACETATEQ2

IMMUNOGLOBULIN AQ3

ENDURANCE TRAININGQ1

CURCUMINQ1

Abstract

Background and Objective: Lead as an environmental pollutant can damage the immune system. This study was done to determine the effect of moderate-intensity exercise and CURCUMIN supplement on serum level of IMMUNOGLOBULIN A in rats exposed to LEAD ACETATE.Methods: In this experimental study, 46 male rats were allocated into six groups including; Control (C), vehicle (V), lead (L), lead and exercise (LE), lead and CURCUMIN (LC), Lead+exercise+curcumin (LEC). Animals in training groups ran on treadmill for 8 weeks (25- 64 minutes per daily, 15-22 meter/minute and 0% grade). Animals in Lead, LE, LC and LEC groups were received LEAD ACETATE (20 mg/kg/bw) and vehicle animals were received ethyl oleat (30 mg/kg/bw) Intraperitoneally for 3 days per week for 8 weeks. Rats in CURCUMIN and LEC groups were received CURCUMIN (30mg/kg/bw), for 3 day per week for 8 weeks. IgA level were measured by single radial immuno diffusion method.Results: LEAD ACETATE significantly increased MDA levels at P<0.05 in animals. IgA level was 0.2, 0.41 and 0.47 mg/dL in Lead, LE and LEC groups (P<0.05).Conclusion: The simultaneous use of endurance exercise training and CURCUMIN due to increased IgA activity has beneficial effects against lead poisoning.

Cites

PROTECTIVE EFFECTS OF VOLUNTARY EXERCISE AND EXTRACT OF SALVIA OFFICINALIS ON DIAZINON INDUCED HEPATOTOXICITY IN RATS

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APA: Copy

MIRDAR, SH., RAMEZANNEZHAD, A., ARZANI, A., ALINEZHAD, M., & HAJIZADE, A.. (2014). EFFECT OF EXERCISE PROGRAM AND CURCUMIN SUPPLEMENTATION ON SERUM LEVEL OF IMMUNOGLOBULIN A IN RATS EXPOSED TO LEAD ACETATE. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 16(1 (49)), 49-54. SID. https://sid.ir/paper/79127/en

Vancouver: Copy

MIRDAR SH., RAMEZANNEZHAD A., ARZANI A., ALINEZHAD M., HAJIZADE A.. EFFECT OF EXERCISE PROGRAM AND CURCUMIN SUPPLEMENTATION ON SERUM LEVEL OF IMMUNOGLOBULIN A IN RATS EXPOSED TO LEAD ACETATE. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;16(1 (49)):49-54. Available from: https://sid.ir/paper/79127/en

IEEE: Copy

SH. MIRDAR, A. RAMEZANNEZHAD, A. ARZANI, M. ALINEZHAD, and A. HAJIZADE, “EFFECT OF EXERCISE PROGRAM AND CURCUMIN SUPPLEMENTATION ON SERUM LEVEL OF IMMUNOGLOBULIN A IN RATS EXPOSED TO LEAD ACETATE,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 16, no. 1 (49), pp. 49–54, 2014, [Online]. Available: https://sid.ir/paper/79127/en

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