EFFECT OF HYDROGEN SULPHIDE ON MOTOR ACTIVITY IN MICE JEJUNUM

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RAHMATI REZA; GRUNDY D.

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Journal: JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES Year:2010 | Volume:11 | Issue:4 (32) Page(s): 16-20

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Title

EFFECT OF HYDROGEN SULPHIDE ON MOTOR ACTIVITY IN MICE JEJUNUM

Author(s)

RAHMATI REZA | GRUNDY D. | Issue Writer Certificate

Keywords

HYDROGEN SULFIDEQ3

MICEQ2

INTESTINEQ2

MOTOR ACTIVITYQ2

Abstract

Background and Objective: Biological activity of hydrogen supplied in smooth muscle of vessel and non-vessel tissue are contradictory. The aim of this study was to examine the effect of hydrogen sulphide on smooth activity of muscle MICE jejunum.Materials and Methods: Experiments were performed on MICE jejunum and MOTOR ACTIVITY was recorded from in vitro segments of jejunum ~ 4 cm in length. jejunal segments were mounted horizontally in separate perfusion chamber. Furthermore, using vanilloid receptor 1 deficient MICE (VR 1-/-) we tested hypothesis that extrinsic sensory nerves mediated alterations, in MOTOR ACTIVITY responses in the presence different concentration of of hydrogen sulphide (100-3000 mM).Results: Serosal application of NaHS (as hydrogen sulphide donor) produced a dose-dependent inhibition of MOTOR ACTIVITY that are not significantly different between VR 1-/- and VR 1 +/+ MICE. In the presence of TTX (1mM) NaHS (300mM) caused a reduction in basal tone (19.5%, p<0.05, n=5) and inhibited the contraction evoked by 30mM bethanechol by 55% (n=5, p<0.05). Conclusion: This study showed that hydrogen sulphide is an important MOTOR ACTIVITY inhibitor in MICE jejunum.

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APA: Copy

RAHMATI, REZA, & GRUNDY, D.. (2010). EFFECT OF HYDROGEN SULPHIDE ON MOTOR ACTIVITY IN MICE JEJUNUM. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 11(4 (32)), 16-20. SID. https://sid.ir/paper/79244/en

Vancouver: Copy

RAHMATI REZA, GRUNDY D.. EFFECT OF HYDROGEN SULPHIDE ON MOTOR ACTIVITY IN MICE JEJUNUM. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2010;11(4 (32)):16-20. Available from: https://sid.ir/paper/79244/en

IEEE: Copy

REZA RAHMATI, and D. GRUNDY, “EFFECT OF HYDROGEN SULPHIDE ON MOTOR ACTIVITY IN MICE JEJUNUM,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 11, no. 4 (32), pp. 16–20, 2010, [Online]. Available: https://sid.ir/paper/79244/en

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