EFFECT OF DONEPEZIL HYDROCHLORIDE ON REFERENCE AND WORKING MEMORY IMPAIRMENT AFTER BILATERAL ELECTRICAL LESION OF NUCLEUS BASALIS MAGNOCELLULARIS IN RATS MODEL OF ALZHEIMER DISEASE

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ESKANDARY AZADE; MOAZEDI AHMAD ALI; NAJAFZADEHVARZI HOSSEIN; AKHOND MOHAMAD REZA

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Journal: JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:20 | Issue:1 (65) Page(s): 36-42

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Title

EFFECT OF DONEPEZIL HYDROCHLORIDE ON REFERENCE AND WORKING MEMORY IMPAIRMENT AFTER BILATERAL ELECTRICAL LESION OF NUCLEUS BASALIS MAGNOCELLULARIS IN RATS MODEL OF ALZHEIMER DISEASE

Author(s)

ESKANDARY AZADE | MOAZEDI AHMAD ALI | NAJAFZADEHVARZI HOSSEIN | AKHOND MOHAMAD REZA | Issue Writer Certificate

Keywords

ALZHEIMER DISEASEQ2

NUCLEUS BASALIS MAGNOCELLULARISQ1

MEMORYQ2

DONEPEZIL HYDROCHLORIDEQ1

RATQ2

Abstract

Background and Objective: Dysfunction and loss of basal forebrain cholinergic neurons and their cortical projections are the earliest pathological events in the pathogenesis of ALZHEIMER DISEASE (AD). This study was done to evaluate the effect of DONEPEZIL HYDROCHLORIDE on reference and working MEMORY caused by mutual electrical lesion of the NUCLEUS BASALIS MAGNOCELLULARIS (NBM) in animal model of AD.Methods: In this experimental study, 56 adult male Wistar RATs were allocated into 8 group (n=7) including: control (intact), NBM lesion group, which received electrically- induced lesion (0.5 m A, 3s) in NBM, Sham group (the electrode was impaled in to the NBM with no lesion), donepezil groups (lesion+0.1, 1, 5, 10 mg/kg/bw of DONEPEZIL HYDROCHLORIDE) and vehicle group (NBM lesion+saline). Acquisition and retention testing were done by using an eight-radial arm maze, in which, the patterns of arm entries in each group was recorded for calculating correct choice, working MEMORY errors, reference MEMORY error and latency.Results: The spatial learning of animals in the lesion of NBM group significantly reduced in compared to controls (P<0.05). Moreover, no effect on spatial learning was seen in the sham group compared with the lesion group. The post-lesion treatment with DONEPEZIL HYDROCHLORIDE in dosedependent manner improved the parameters of spatial MEMORY errors in the acquisition and retention tasks in comparision with the lesion group (P<0.05).Conclusion: Treatment with DONEPEZIL HYDROCHLORIDE, dose-dependently improves cognitive impairment induced by the destruction of the NUCLEUS BASALIS MAGNOCELLULARIS.

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APA: Copy

ESKANDARY, AZADE, MOAZEDI, AHMAD ALI, NAJAFZADEHVARZI, HOSSEIN, & AKHOND, MOHAMAD REZA. (2018). EFFECT OF DONEPEZIL HYDROCHLORIDE ON REFERENCE AND WORKING MEMORY IMPAIRMENT AFTER BILATERAL ELECTRICAL LESION OF NUCLEUS BASALIS MAGNOCELLULARIS IN RATS MODEL OF ALZHEIMER DISEASE. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 20(1 (65) ), 36-42. SID. https://sid.ir/paper/79308/en

Vancouver: Copy

ESKANDARY AZADE, MOAZEDI AHMAD ALI, NAJAFZADEHVARZI HOSSEIN, AKHOND MOHAMAD REZA. EFFECT OF DONEPEZIL HYDROCHLORIDE ON REFERENCE AND WORKING MEMORY IMPAIRMENT AFTER BILATERAL ELECTRICAL LESION OF NUCLEUS BASALIS MAGNOCELLULARIS IN RATS MODEL OF ALZHEIMER DISEASE. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;20(1 (65) ):36-42. Available from: https://sid.ir/paper/79308/en

IEEE: Copy

AZADE ESKANDARY, AHMAD ALI MOAZEDI, HOSSEIN NAJAFZADEHVARZI, and MOHAMAD REZA AKHOND, “EFFECT OF DONEPEZIL HYDROCHLORIDE ON REFERENCE AND WORKING MEMORY IMPAIRMENT AFTER BILATERAL ELECTRICAL LESION OF NUCLEUS BASALIS MAGNOCELLULARIS IN RATS MODEL OF ALZHEIMER DISEASE,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 20, no. 1 (65) , pp. 36–42, 2018, [Online]. Available: https://sid.ir/paper/79308/en

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