EFFECT OF β ESTRADIOL ON TRAUMATIC MEMORY AFTER POSTTRAUMATIC STRESS DISORDER INDUCED BY MODIFIED SINGLE-PROLONGED STRESS MODEL IN MALE RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MIRSHEKAR M.; ABRARI K.; GOUDARZI I.; RASHIDY POUR A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES Year:2013 | Volume:15 | Issue:1 (45) Page(s): 25-30

Download Full-Text

Persian Verion

View:

740

Download:

Cites:

Information Journal Paper

Title

EFFECT OF β ESTRADIOL ON TRAUMATIC MEMORY AFTER POSTTRAUMATIC STRESS DISORDER INDUCED BY MODIFIED SINGLE-PROLONGED STRESS MODEL IN MALE RATS

Author(s)

MIRSHEKAR M. | ABRARI K. | GOUDARZI I. | RASHIDY POUR A. | Issue Writer Certificate

Keywords

PTSDQ2

SPS&SQ2

β-ESTRADIOLQ2

TRAUMATIC MEMORYQ2

Abstract

Background and Objective: Post-traumatic stress disorder (PTSD) is an anxiety, which is induced by exposure to life-threatening trauma and produces memory dysfunctions. This study was done to evaluate the effect of b-estradiol on TRAUMATIC MEMORY after post-traumatic stress disorder induced by modified single-prolonged stress model in male rats.Materials and Methods: This experimental study was done on 70 male Wistar rats, weighted 200-250 grams. Initially 30 rats randomly allocated into control, shock and single prolonged stress accompanied shock (SPS&S). In SPS&S group immobilized for 2h, followed immediately with a 20 min forced swim conducted in a cylindrical filled with water. After recuperating for 15 min, animals anesthetized with ether. After 30 min recovery, stressed rats placed in the conditioned fear system (CFS). They received one 1mA, 4 second electric foot shock and remained in the chamber for another 60 second before being returned to their home cages. Shock group: Animals placed in CFS and only received the same shock as previous experiment. Naive group: Animals were removed from their home cages and exposed to chamber without receiving any foot shock. 1, 2 and 3 week later, animals in all groups were re-exposed to the shock chamber for 3 min, in order to examine conditioned fear response. In the second experiment rats were injected with b-estradiol (90 mg/kg), one and two week after training. Date were analyzed using SPSS-16, ANOVA and LSD tests.Results: SPS&S significantly induced freezing response (traumatic memory) compared with controls and shock groups (P<0.05) following three weeks. This response significantly reduced due to repetitive injection of b-estradiol in rats (P<0.05). After three weeks causes of enhanced freezing response (traumatic memory) compare with both, shock and sham groups (P<0.001). b-estradiol significantly reduced this response in rats (P<0.001).Conclusion:b-estradiol's administration following PTSD induction by modified single-prolonged stress, significantly decreased the freezing response. Therefore, b-estradiol can prevent the formation of TRAUMATIC MEMORY.

Cites

No record.

References

Cite

APA: Copy

MIRSHEKAR, M., ABRARI, K., GOUDARZI, I., & RASHIDY POUR, A.. (2013). EFFECT OF β ESTRADIOL ON TRAUMATIC MEMORY AFTER POSTTRAUMATIC STRESS DISORDER INDUCED BY MODIFIED SINGLE-PROLONGED STRESS MODEL IN MALE RATS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 15(1 (45)), 25-30. SID. https://sid.ir/paper/79663/en

Vancouver: Copy

MIRSHEKAR M., ABRARI K., GOUDARZI I., RASHIDY POUR A.. EFFECT OF β ESTRADIOL ON TRAUMATIC MEMORY AFTER POSTTRAUMATIC STRESS DISORDER INDUCED BY MODIFIED SINGLE-PROLONGED STRESS MODEL IN MALE RATS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2013;15(1 (45)):25-30. Available from: https://sid.ir/paper/79663/en

IEEE: Copy

M. MIRSHEKAR, K. ABRARI, I. GOUDARZI, and A. RASHIDY POUR, “EFFECT OF β ESTRADIOL ON TRAUMATIC MEMORY AFTER POSTTRAUMATIC STRESS DISORDER INDUCED BY MODIFIED SINGLE-PROLONGED STRESS MODEL IN MALE RATS,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 15, no. 1 (45), pp. 25–30, 2013, [Online]. Available: https://sid.ir/paper/79663/en

Related Journal Papers