EFFECT OF PALMATINE HYDROCHLORIDE ON IMPROVEMENT OF COGNITIVE DYSFUNCTION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AHOUEI M.; VAEZI GH.; KALALIAN MOGHADDAM H.; ALAMALHODA F.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES Year:2013 | Volume:15 | Issue:1 (45) Page(s): 38-44

Download Full-Text

Persian Verion

View:

829

Download:

Cites:

Information Journal Paper

Title

EFFECT OF PALMATINE HYDROCHLORIDE ON IMPROVEMENT OF COGNITIVE DYSFUNCTION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

Author(s)

AHOUEI M. | VAEZI GH. | KALALIAN MOGHADDAM H. | ALAMALHODA F. | Issue Writer Certificate

Keywords

DIABETES MELLITUSQ2

PALMATINE HYDROCHLORIDEQ2

COGNITIVE DYSFUNCTIONSQ2

MEMORYQ2

LEARNINGQ2

Abstract

Background and Objective: Recent studies have shown that diabetes induced cognitive dysfunction and impairs LEARNING and MEMORY. Palmatine is an isoquinoline alkaloid, and has multiple pharmacological effects, including anti-diabetic and antioxidant activity. This study was conducted, to evaluate the effect of Palmatine on LEARNING and spatial MEMORY impairment in STZ-induced diabetic rats.Materials and Methods: This experimental study was conducted on the male Wistar rats (n=32) with approximate weight of 240 ±40 grams. The rats were randomly allocated and were divided into 4 groups (n=8): Control, Palmatine-treated non-diabetic, diabetic and Palmatine-treated diabetic groups. Diabetes was induced by STZ administration at the dose of 55 mg/kg through intraperitoneal route. PALMATINE HYDROCHLORIDE was administered subcutaneous at doses of 10 mg/kg/day 1 week after STZ injection for a period of 6 weeks. Blood samples were taken from the tail vein 1, 3, 5, 7 weeks after STZ injection to measure blood glucose levels. Behavioral tests including spatial recognition and objective recognition were performed at the end of study. Data were analyzed by using Prism-5, one way ANOVA and Tukey tests.Results: In spatial recognition test, the number of entrance in new arm of the Ymaze, in the Palmatine-treated groups significantly increased in compare to diabetic group in both sixth and seventh weeks (P<0.05). Number of rearing in new arm significantly increased in sixth and seventh weeks, compare to the diabetic group (P<0.05). The number of recognition novel objects in the Palmatine-treated diabetic group significantly increased in compare to diabetic group (P<0.05).Conclusion: PALMATINE HYDROCHLORIDE administration for 6 weeks improves cognitive dysfunction in streptozotocin-induced diabetic rats.

Cites

PALMATINE HYDROCHLORIDE IMPROVES MOTOR DYSFUNCTION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

References

Cite

APA: Copy

AHOUEI, M., VAEZI, GH., KALALIAN MOGHADDAM, H., & ALAMALHODA, F.. (2013). EFFECT OF PALMATINE HYDROCHLORIDE ON IMPROVEMENT OF COGNITIVE DYSFUNCTION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 15(1 (45)), 38-44. SID. https://sid.ir/paper/79664/en

Vancouver: Copy

AHOUEI M., VAEZI GH., KALALIAN MOGHADDAM H., ALAMALHODA F.. EFFECT OF PALMATINE HYDROCHLORIDE ON IMPROVEMENT OF COGNITIVE DYSFUNCTION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2013;15(1 (45)):38-44. Available from: https://sid.ir/paper/79664/en

IEEE: Copy

M. AHOUEI, GH. VAEZI, H. KALALIAN MOGHADDAM, and F. ALAMALHODA, “EFFECT OF PALMATINE HYDROCHLORIDE ON IMPROVEMENT OF COGNITIVE DYSFUNCTION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 15, no. 1 (45), pp. 38–44, 2013, [Online]. Available: https://sid.ir/paper/79664/en

Related Journal Papers