THE ROLE OF MUSCARINIC RECEPTORS IN CONTRACTIONS OF ADULT MALE RAT'S ISOLATED ILEUM

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

TAVALAEE R.; MOAZEDI A.A.; Gharibnaseri M.K.; AKHOND M.R.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Yafteh Year:2017 | Volume:19 | Issue:2 (72) Page(s): 103-114

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

917

Download:

Cites:

Information Journal Paper

Title

THE ROLE OF MUSCARINIC RECEPTORS IN CONTRACTIONS OF ADULT MALE RAT'S ISOLATED ILEUM

Author(s)

TAVALAEE R. | MOAZEDI A.A. | Gharibnaseri M.K. | AKHOND M.R. | Issue Writer Certificate

Keywords

CONTRACTIONQ2

ILEUMQ3

CARBACHOLQ2

SCOPOLAMINEQ2

RATQ2

Abstract

Background: The effects of cholinergic system are applied through both nicotine and muscarinic receptors. Considering to muscarinic receptors existence in the RAT ILEUM, in this research the effect of CARBACHOL (muscarinic receptor agonist) and SCOPOLAMINE (muscarinic receptor antagonists) on the ILEUM CONTRACTION induced by KCl in adult male RATs were studied.Materials and Methods: The distal part of Wistar RAT’s ILEUM was separated and its CONTRACTIONs were recorded under one gr stretching and 37 degree temperature in the bathroom containing the solution of Tyrode by Isotonic method. The ILEUM tissue separately affected byKCl then CARBACHOL in the first group, KCl then SCOPOLAMINE in the second group, SCOPOLAMINE for 30 minutes then KCl in the third group and 10-3 M concentration of SCOPOLAMINE for 30 minutes then 10-2 M concentration CARBACHOL in the fourth group.Results: There was a significant difference between zero concentration and (10-2, 10-3, 10-4mg/ml) concentrations of CARBACHOL (P<0.001). There was a significant difference between zero concentration and 10-3 M concentration of SCOPOLAMINE (P<0.01) and also the values of 10-4, 10-6M (P<0.001). There was a significant difference between zero concentration and 10-3 M concentration of SCOPOLAMINE (P<0.01) and also the values of 10-4M (P<0.001) and 10-6M (P<0.05) when SCOPOLAMINE was exposed tissue for 30 minutes.Conclusion: This study showed that different concentrations of CARBACHOL enhance induced CONTRACTION by potassium chloride in a concentration-dependent manner and has a synergistic effect with potassium chloride. Also, different concentrations of SCOPOLAMINE decrease induced CONTRACTION by potassium chloride in a concentration-dependent manner.

Cites

No record.

References

Cite

APA: Copy

TAVALAEE, R., MOAZEDI, A.A., Gharibnaseri, M.K., & AKHOND, M.R.. (2017). THE ROLE OF MUSCARINIC RECEPTORS IN CONTRACTIONS OF ADULT MALE RAT'S ISOLATED ILEUM. YAFTEH, 19(2 (72)), 103-114. SID. https://sid.ir/paper/79810/en

Vancouver: Copy

TAVALAEE R., MOAZEDI A.A., Gharibnaseri M.K., AKHOND M.R.. THE ROLE OF MUSCARINIC RECEPTORS IN CONTRACTIONS OF ADULT MALE RAT'S ISOLATED ILEUM. YAFTEH[Internet]. 2017;19(2 (72)):103-114. Available from: https://sid.ir/paper/79810/en

IEEE: Copy

R. TAVALAEE, A.A. MOAZEDI, M.K. Gharibnaseri, and M.R. AKHOND, “THE ROLE OF MUSCARINIC RECEPTORS IN CONTRACTIONS OF ADULT MALE RAT'S ISOLATED ILEUM,” YAFTEH, vol. 19, no. 2 (72), pp. 103–114, 2017, [Online]. Available: https://sid.ir/paper/79810/en

Related Journal Papers