ASSESSMENT OF THE CYTOTOXICITY AND IN VIVO ANTI-PLASMODIAL ACTIVITY OF ETHANOL AND DICHLOROMETHANE EXTRACTS OF FOUR DIFFERENT IRANINAN PROPOLIS

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AFROUZAN H.; ABOUIE MEHRIZI A.; SHOKRGOZAR S.; Tahghighi A.; ES HAGHI A.; DINPARAST DGADID N.; ZAKERI S.

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Journal: Yafteh Year:2017 | Volume:19 | Issue:2 (72) Page(s): 115-125

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Title

ASSESSMENT OF THE CYTOTOXICITY AND IN VIVO ANTI-PLASMODIAL ACTIVITY OF ETHANOL AND DICHLOROMETHANE EXTRACTS OF FOUR DIFFERENT IRANINAN PROPOLIS

Author(s)

Keywords

IRANQ2

PROPOLISQ2

CYTOTOXICITYQ2

ANTI-PLASMODIUMQ1

Abstract

Background: The emergence of antimalarial drug resistance is one of the great problems of malaria control and elimination of worldwide. In order to overcome anti -malarial drug resistance, CYTOTOXICITY andin vivo anti- Plasmodiumal activity of four different IRANian PROPOLIS were investigated.Materials and Methods: Four IRANian PROPOLIS samples were collected from four different regions of IRAN and extracted by %70 ethanol and dichloromethane. The CYTOTOXICITY of ethanolic and dichloromethane extract of PROPOLIS, using L969 fibroblast cell lines, were evaluated by MTT assay. The in vitroanti- Plasmodial activities of the PROPOLIS samples on BALB/c mice were assayed.Results: The CYTOTOXICITY results showed that ethanol and dichloromethane extracts of four IRANian PROPOLIS samples at doses of 25, 50, 100 and 200 mg/ml were non-toxic (P<0.05). The highest percentage of growth inhibition against Plasmodium berghei with %71 and %65 was for ethanol and dichloromethane extract of Morad Byge PROPOLIS, respectively.Conclusion: Considering the drug resistance of P. falciparum to conventional medicine and its dangers, and the emergence of development cheap and safe anti-malaria drugs to control and eliminate programs. Further investigation on IRANian PROPOLIS as safe and anti-malarial drug is recommended.

Cites

A Study on the Effect of Zingiber Officinale Hydroalcoholic Extract on Plasmodium berghei in Infected Mice: An Experimental Study

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APA: Copy

AFROUZAN, H., ABOUIE MEHRIZI, A., SHOKRGOZAR, S., Tahghighi, A., ES HAGHI, A., DINPARAST DGADID, N., & ZAKERI, S.. (2017). ASSESSMENT OF THE CYTOTOXICITY AND IN VIVO ANTI-PLASMODIAL ACTIVITY OF ETHANOL AND DICHLOROMETHANE EXTRACTS OF FOUR DIFFERENT IRANINAN PROPOLIS. YAFTEH, 19(2 (72)), 115-125. SID. https://sid.ir/paper/79812/en

Vancouver: Copy

AFROUZAN H., ABOUIE MEHRIZI A., SHOKRGOZAR S., Tahghighi A., ES HAGHI A., DINPARAST DGADID N., ZAKERI S.. ASSESSMENT OF THE CYTOTOXICITY AND IN VIVO ANTI-PLASMODIAL ACTIVITY OF ETHANOL AND DICHLOROMETHANE EXTRACTS OF FOUR DIFFERENT IRANINAN PROPOLIS. YAFTEH[Internet]. 2017;19(2 (72)):115-125. Available from: https://sid.ir/paper/79812/en

IEEE: Copy

H. AFROUZAN, A. ABOUIE MEHRIZI, S. SHOKRGOZAR, A. Tahghighi, A. ES HAGHI, N. DINPARAST DGADID, and S. ZAKERI, “ASSESSMENT OF THE CYTOTOXICITY AND IN VIVO ANTI-PLASMODIAL ACTIVITY OF ETHANOL AND DICHLOROMETHANE EXTRACTS OF FOUR DIFFERENT IRANINAN PROPOLIS,” YAFTEH, vol. 19, no. 2 (72), pp. 115–125, 2017, [Online]. Available: https://sid.ir/paper/79812/en

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