QUERCETIN FLAVONOID AND NON-ALCOHOLIC FATTY LIVER DISEASE

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EMAMAT MOHAMAD HADI; MIRMIRAN PARVIN; HEKMATDOOST AZITA

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Paper Information

Journal: Yafteh Year:2016 | Volume:18 | Issue:1 (67) Page(s): 90-100

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Title

QUERCETIN FLAVONOID AND NON-ALCOHOLIC FATTY LIVER DISEASE

Author(s)

EMAMAT MOHAMAD HADI | MIRMIRAN PARVIN | HEKMATDOOST AZITA | Issue Writer Certificate

Keywords

QUERCETINQ1

NONQ1

ALCOHOLIC FATTY LIVER DISEASEQ1

ANTIOXIDANTQ1

INSULIN RESISTANCEQ2

INFLAMMATIONQ2

Abstract

Background: The prevalence of NON-alcoholic fatty liver disease (NAFLD) increased globally. Prevalence of NAFLD in general population estimated as 10-24%. INSULIN RESISTANCE and fat accumulation in liver cells playing an important role in this disease. Recently usage of ANTIOXIDANTs in prevention and treatment of disease is considered. QUERCETIN is an ANTIOXIDANT in flavonoids group. In the present study we aim to determine the effects of QUERCETIN on NAFLD.Materials and Methods: After searching relevant keywords such as NAFLD, ANTIOXIDANT, QUERCETIN, INSULIN RESISTANCE, liver activity, lipid and INFLAMMATION, 20 fulltext papers and 12 abstracts that which were in accordance with the aim of this study were evaluated.Results: QUERCETIN in addition to its inherent ANTIOXIDANT activity can reduce INFLAMMATION; improve serum lipids; decrease lipid accumulation in the liver; improve INSULIN RESISTANCE by increasing hexokinase activity, glycogen content of muscle and liver, phosphorylation and activation of insulin receptors; and promote liver activity by reducing serum liver transaminase enzymes and inhibiting the production of liver fibrotic factors.Conclusion: In animal and cell-culture studies, the application of QUERCETIN was shown to have ANTIOXIDANT, anti-inflammatory, hypolipidemic, INSULIN RESISTANCE reduction and antifibrotic effects. All these factors clearly show that QUERCETIN can be counted as one of the important dietary factors having a role in the prevention and also treatment of NAFLD.

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APA: Copy

EMAMAT, MOHAMAD HADI, MIRMIRAN, PARVIN, & HEKMATDOOST, AZITA. (2016). QUERCETIN FLAVONOID AND NON-ALCOHOLIC FATTY LIVER DISEASE. YAFTEH, 18(1 (67)), 90-100. SID. https://sid.ir/paper/79999/en

Vancouver: Copy

EMAMAT MOHAMAD HADI, MIRMIRAN PARVIN, HEKMATDOOST AZITA. QUERCETIN FLAVONOID AND NON-ALCOHOLIC FATTY LIVER DISEASE. YAFTEH[Internet]. 2016;18(1 (67)):90-100. Available from: https://sid.ir/paper/79999/en

IEEE: Copy

MOHAMAD HADI EMAMAT, PARVIN MIRMIRAN, and AZITA HEKMATDOOST, “QUERCETIN FLAVONOID AND NON-ALCOHOLIC FATTY LIVER DISEASE,” YAFTEH, vol. 18, no. 1 (67), pp. 90–100, 2016, [Online]. Available: https://sid.ir/paper/79999/en

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