HLA –DRB1*, DQB1* ALLELES IN HYDATID PATIENTS BY MOLECULAR TYPING

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MOSAYEBI M.; DALIMIASL A.A.H.; MOAZENI S.M.; MOSAYEBI GHASEM

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Paper Information

Journal: Yafteh Year:2007 | Volume:9 | Issue:3 (33) Page(s): 11-20

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Information Journal Paper

Title

HLA –DRB1, DQB1 ALLELES IN HYDATID PATIENTS BY MOLECULAR TYPING

Author(s)

MOSAYEBI M. | DALIMIASL A.A.H. | MOAZENI S.M. | MOSAYEBI GHASEM | Issue Writer Certificate

Keywords

HYDATIDOSQ3

HLA-DRB1**Q3

DQB1**Q3

ALLELEQ3

PCR-SSPQ2

IRANIAN PATIENTQ4

Abstract

Background: HYDATIDOSis is a important disease that results from infection with larvae of the dog tape worm, Echinococcus granulosus in human and farm animals. Resistance or susceptibility to infectious diseases, for example, cystic and alveolar echinococcosis is restricted by individual host factors and immunologic responses, in many surveys has been shown. The target of this study that is the first survey dealing with the correlation between HLA-DRB1**& DQB1** ALLELEs and cystic echinococcosis in IRANIAN PATIENT,is investigation HLA-DRB1**and DQB1** allelic polymorphism in IRANIAN PATIENT with HYDATIDOSis.Materials and methods: The study was carried out on 56 patients with confirmed cystic echinococcosis and 30 apparently healthy individuals living on Arak area by HLA-DRB1**& DQB1** typing with PCR-SSP method. The first step was founding patients and blood sampling. DNA was prepared from whole blood and we used PCR-SSP with 31 primer mixes for per sample. PCR reaction mixtures were loaded in agar’s gels and after electrophoresis, geles were examined under UV illumination and gel document. Analyse of results carried out with specific software and frequency& interpretation tables and homogeneity test for calculation of P-value in x2 test with fisher’s exact test. significant samples with logistic regression analysed and Odds-ratio calculate.Results: A statistically significant positive association was found between HLA-DQB1*02 and the occurrence of cystic echinococcosis (P<0.05), (Odds-ratio=2.87).Conclusion: The most useful markers of HLA exists for the study of the relationship between genetical background and cystic echinococcosis with molecular high resolution methods.

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APA: Copy

MOSAYEBI, M., DALIMIASL, A.A.H., MOAZENI, S.M., & MOSAYEBI, GHASEM. (2007). HLA –DRB1*, DQB1* ALLELES IN HYDATID PATIENTS BY MOLECULAR TYPING. YAFTEH, 9(3 (33)), 11-20. SID. https://sid.ir/paper/80140/en

Vancouver: Copy

MOSAYEBI M., DALIMIASL A.A.H., MOAZENI S.M., MOSAYEBI GHASEM. HLA –DRB1*, DQB1* ALLELES IN HYDATID PATIENTS BY MOLECULAR TYPING. YAFTEH[Internet]. 2007;9(3 (33)):11-20. Available from: https://sid.ir/paper/80140/en

IEEE: Copy

M. MOSAYEBI, A.A.H. DALIMIASL, S.M. MOAZENI, and GHASEM MOSAYEBI, “HLA –DRB1*, DQB1* ALLELES IN HYDATID PATIENTS BY MOLECULAR TYPING,” YAFTEH, vol. 9, no. 3 (33), pp. 11–20, 2007, [Online]. Available: https://sid.ir/paper/80140/en

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