HUMAN PLATELET ANTIGEN POLYMORPHISM IN BRONCHIAL ASTHMA

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NADI EBRAHIM; HAJILOUEI M.; ROUSHANI M.; TAVANA S.; MAHJOUB H.

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Journal: Yafteh Year:2006 | Volume:8 | Issue:2 (28) Page(s): 61-69

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Title

HUMAN PLATELET ANTIGEN POLYMORPHISM IN BRONCHIAL ASTHMA

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Keywords

ASTHMAQ3

HUMAN PLATELET ANTIGEN-1(HPA-1)Q3

POLYMORPHISMQ2

Abstract

Background: ASTHMA is recognized as a common cause of disability, of great economic cost, and of preventable deaths. In this study we aimed to test our hypothesis to evaluate the relationship between the Human Platelet Antigen-1(HPA-I) POLYMORPHISM and bronchial ASTHMA and its severity, which would suggest genetic variances that may be responsible for expression or activation of these receptors, so play a role in explaining the suggested genotypic differences in the risk of bronchial ASTHMA occurrence.Materials and methods: To investigate the relation between the HPA-I POLYMORPHISM and bronchial ASTHMA, we conducted a case-control study of 110 patients with bronchial ASTHMA and 129 non-ASTHMAtic outpatient controls, which were participated voluntarily in this study. After the participants answered a questionnaire aimed at identifying their age, sex, clinical signs and symptoms to identify ASTHMA severity, a trained observer assessed airway reversibility in ASTHMAtic patients. To determine HPA-I allele frequencies (la, Ib) and genotyping for Ia+Ia, Ia+Ib and Ib+Ib in both patients and controls, a blood sample was sent to the laboratory.Results: It was found that the dyspnea was the most common symptom in ASTHMAtic patients, recurrent episodic wheezing (93.6%), cough (90%) and nocturnal symptom (89.1%) were other more common symptoms respectively. Assessment of HPA-1 allele frequencies (Ia, Ib) and genotyping for Ia+la, Ia+Ib and Ib+Ib showed no differences in both patients and controls (P>0.05). The rate of Ia allele frequency and Ia+Ia genotype had a direct relationship with ASTHMA severity. Conclusion: We observed strong association between HPA-1 a allele and ASTHMA severity, but no association between the presence of HPA-1 POLYMORPHISM and bronchial ASTHMA.

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APA: Copy

NADI, EBRAHIM, HAJILOUEI, M., ROUSHANI, M., TAVANA, S., & MAHJOUB, H.. (2006). HUMAN PLATELET ANTIGEN POLYMORPHISM IN BRONCHIAL ASTHMA. YAFTEH, 8(2 (28)), 61-69. SID. https://sid.ir/paper/80304/en

Vancouver: Copy

NADI EBRAHIM, HAJILOUEI M., ROUSHANI M., TAVANA S., MAHJOUB H.. HUMAN PLATELET ANTIGEN POLYMORPHISM IN BRONCHIAL ASTHMA. YAFTEH[Internet]. 2006;8(2 (28)):61-69. Available from: https://sid.ir/paper/80304/en

IEEE: Copy

EBRAHIM NADI, M. HAJILOUEI, M. ROUSHANI, S. TAVANA, and H. MAHJOUB, “HUMAN PLATELET ANTIGEN POLYMORPHISM IN BRONCHIAL ASTHMA,” YAFTEH, vol. 8, no. 2 (28), pp. 61–69, 2006, [Online]. Available: https://sid.ir/paper/80304/en

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