EFFECTS OF PLATELET MICROPARTICLES ON THE ACTIVATION OF B CELLS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ESMAILI MOHAMAD ALI; YARI FATEMEH; SHARIFI ZOHREH; NIKOUGOFTAR MAHIN; FADAEI RAZIEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Pathobiology Research Year:2013 | Volume:15 | Issue:4 Page(s): 1-10

Download Full-Text

Persian Verion

View:

744

Download:

Cites:

Information Journal Paper

Title

EFFECTS OF PLATELET MICROPARTICLES ON THE ACTIVATION OF B CELLS

Author(s)

Keywords

PLATELETQ2

MICROPARTICLESQ2

B CELLSQ2

CD27Q2

CD86Q3

IGDQ3

Abstract

Objectives: PLATELETs are anucleated fragments derived from megakaryocytes. It has been demonstrated that PLATELETs play a role in hemostasis and innate immunity. In addition, PLATELETs have a CD40 ligand which is an important molecular marker in motivating immune cells. Thus, PLATELETs also have a role in adaptive immunity as seen by their ability to activate B CELLS. Since human PLATELET MICROPARTICLES (MPs) originate from PLATELETs, we have chosen to examine the effects of MPs on B cell activation.Methods: PLATELET MPs were isolated from PLATELET concentrates obtained from the Tehran Blood Transfusion Center. The MPs were co-cultured with B CELLS isolated from human whole blood with magnetic beads using negative selection. After seven days, the expression of activation markers CD27 and CD86, as well as IGD were evaluated by flow cytometry.Results: In a comparison between test (B cells/MPs) and control (B cells) cells we observed that the expression of activation markers CD27 and CD86 increased during the seven-day co-culture period. However, the expression of IGD antibody decreased.Conclusions: As with PLATELETs, MPs can affect B cell activation during in vitro coculture.

Cites

EFFECTS OF SPEED AND TIME OF CENTRIFUGATION AND TIME OF FREEZING ON THE AMOUNT OF PRODUCED MICROPARTICLES FROM CONCENTRATES PLATELET

References

No record.

Cite

APA: Copy

ESMAILI, MOHAMAD ALI, YARI, FATEMEH, SHARIFI, ZOHREH, NIKOUGOFTAR, MAHIN, & FADAEI, RAZIEH. (2013). EFFECTS OF PLATELET MICROPARTICLES ON THE ACTIVATION OF B CELLS. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 15(4), 1-10. SID. https://sid.ir/paper/81006/en

Vancouver: Copy

ESMAILI MOHAMAD ALI, YARI FATEMEH, SHARIFI ZOHREH, NIKOUGOFTAR MAHIN, FADAEI RAZIEH. EFFECTS OF PLATELET MICROPARTICLES ON THE ACTIVATION OF B CELLS. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2013;15(4):1-10. Available from: https://sid.ir/paper/81006/en

IEEE: Copy

MOHAMAD ALI ESMAILI, FATEMEH YARI, ZOHREH SHARIFI, MAHIN NIKOUGOFTAR, and RAZIEH FADAEI, “EFFECTS OF PLATELET MICROPARTICLES ON THE ACTIVATION OF B CELLS,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 15, no. 4, pp. 1–10, 2013, [Online]. Available: https://sid.ir/paper/81006/en

Related Journal Papers