METHYLATION PATTERN OF HEPATITIS B VIRUS X GENE IN INFECTED PATIENTS

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HOSSEINI FATEMEH; RAVANSHAD MEHRDAD; NORUZINIA MEHRDAD

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Journal: Pathobiology Research Year:2014 | Volume:16 | Issue:4 Page(s): 39-46

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Title

METHYLATION PATTERN OF HEPATITIS B VIRUS X GENE IN INFECTED PATIENTS

Author(s)

HOSSEINI FATEMEH | RAVANSHAD MEHRDAD | NORUZINIA MEHRDAD | Issue Writer Certificate

Keywords

HEPATITIS BQ2

DNA METHYLATIONQ3

EPIGENETICQ2

Abstract

Objective: A recent field of research in EPIGENETICs is DNA METHYLATION which involves the CpG island in the genome that subsequently controls transcription and translation of targeted genes. In the HEPATITIS B virus (HBV) genome, there are three CpG islands which tend to be methylated. The aim of the current study is to determine the methylation pattern of the HBV X gene in chronically infected HBV patients.Methods: Study participants comprised 45 chronically infected HBV patients. According to the presence of the HBeAg, patients were divided into two groups, HBeAg positive (n=24) and HBeAg negative (n=21). Initially, viral DNA was treated with natrium bisulfate. Then, analysis was performed with two sets of methylated and non-methylated primers by the MSP method.Results: The overall methylation rate in serum samples of HEPATITIS B infected patients was 35.5%; the rate in the HBeAg positive patients was 20.8%, whereas it was 52.3% in HBeAg negative patients. There was a significantly higher rate of methylation in serum samples of HBeAg negative patients compared to HBeAg positive patients (student's ttest; P=0.02).Conclusion: Methylation of HBV can be used as a new mechanism to control the progression of viral infection. This methodology can be useful for determining the characteristics of clinical stages of this infection.

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APA: Copy

HOSSEINI, FATEMEH, RAVANSHAD, MEHRDAD, & NORUZINIA, MEHRDAD. (2014). METHYLATION PATTERN OF HEPATITIS B VIRUS X GENE IN INFECTED PATIENTS. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 16(4), 39-46. SID. https://sid.ir/paper/81275/en

Vancouver: Copy

HOSSEINI FATEMEH, RAVANSHAD MEHRDAD, NORUZINIA MEHRDAD. METHYLATION PATTERN OF HEPATITIS B VIRUS X GENE IN INFECTED PATIENTS. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2014;16(4):39-46. Available from: https://sid.ir/paper/81275/en

IEEE: Copy

FATEMEH HOSSEINI, MEHRDAD RAVANSHAD, and MEHRDAD NORUZINIA, “METHYLATION PATTERN OF HEPATITIS B VIRUS X GENE IN INFECTED PATIENTS,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 16, no. 4, pp. 39–46, 2014, [Online]. Available: https://sid.ir/paper/81275/en

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