DETECTION OF PHENAZINE GENES IN MULTI-DRUG RESISTANT PSEUDOMONAS AERUGINOSA ISOLATES

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TUTUNCHI FARNAZ; ZEIGHAMI HABIB

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Journal: Pathobiology Research Year:2016 | Volume:19 | Issue:1 Page(s): 1-11

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Information Journal Paper

Title

DETECTION OF PHENAZINE GENES IN MULTI-DRUG RESISTANT PSEUDOMONAS AERUGINOSA ISOLATES

Author(s)

TUTUNCHI FARNAZ | ZEIGHAMI HABIB | Issue Writer Certificate

Keywords

PSEUDOMONAS AERUGINOSAQ2

MULTIDRUG RESISTANTQ2

PHENAZINEQ1

Abstract

Objective: PSEUDOMONAS AERUGINOSA (P. aeruginosa) is an opportunistic pathogen with numerous virulence factors considered to be one of the most etiological agents in nosocomial infections. The emergence of multi-drug resistant (MDR)P. aeruginosa has become a serious, worldwide public health threat. This study intended to determine the frequency ofphzM, phzS, phzH, phzI, and phzII genes in MDR P. aeruginosa strains isolated from clinical samples.Methods: In this cross-sectional study, we examined 93 isolates of P. aeruginosa collected from different clinical samples in Zanjan during 1393-94. After identification of isolates by biochemical tests, we performed the antibiotic susceptibility test (Kirby-Bauer) per CLSI guidelines. Then, total DNA was extracted for PCR analysis to detectphzM, phzS, phzH, phzI, and phzII genes.Results: P. aeruginosa isolates exhibited high-level resistance to Erythromycin and Cefoxitin (95.6%). Amikacin showed the highest activity against isolates with 73.2% susceptibility. There were 88 (94.6%) MDR isolates. The genes had the following frequency among MDR isolates: phzI (96.5%), phzII (93.1%), phzM (45.4%), phzS (27.2%), andphzH (27.2%).Conclusion: The pathogenesis of P. aeruginosa is clearly multifactorial as shown by the large numbers of virulence factors and the broad spectrum of diseases this bacterium causes. The results indicated a greater frequency ofphzI and phzII genes in MDR P. aeruginosastrains. This finding could be an alarm for the infections caused by this microorganism.

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APA: Copy

TUTUNCHI, FARNAZ, & ZEIGHAMI, HABIB. (2016). DETECTION OF PHENAZINE GENES IN MULTI-DRUG RESISTANT PSEUDOMONAS AERUGINOSA ISOLATES. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 19(1), 1-11. SID. https://sid.ir/paper/81357/en

Vancouver: Copy

TUTUNCHI FARNAZ, ZEIGHAMI HABIB. DETECTION OF PHENAZINE GENES IN MULTI-DRUG RESISTANT PSEUDOMONAS AERUGINOSA ISOLATES. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2016;19(1):1-11. Available from: https://sid.ir/paper/81357/en

IEEE: Copy

FARNAZ TUTUNCHI, and HABIB ZEIGHAMI, “DETECTION OF PHENAZINE GENES IN MULTI-DRUG RESISTANT PSEUDOMONAS AERUGINOSA ISOLATES,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 19, no. 1, pp. 1–11, 2016, [Online]. Available: https://sid.ir/paper/81357/en

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