INHIBITION OF MICROSOME-MEDIATED BINDING OF BENZO (Α) PYRENE TO

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MOHAMMADI QANATGHESTANI M.; ALAMEH A.A.A.; ASSADI MH.; KHAGEH M.R.

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Journal: Anatomical Sciences Journal Year:2003 | Volume:1 | Issue:4 Page(s): 53-62

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Title

INHIBITION OF MICROSOME-MEDIATED BINDING OF BENZO (Α) PYRENE TO"DNA BY CYTOSOLIC REACTION FROM LIVER AND SKIN RATS IN CVITRO

Author(s)

MOHAMMADI QANATGHESTANI M. | ALAMEH A.A.A. | ASSADI MH. | KHAGEH M.R. | Issue Writer Certificate

Keywords

BENZO (Α) PYRENEQ4

DNAQ3

GLUTATHIONEQ3

RATQ3

Abstract

Purpose: The aim of this study was to evaluate the effect of age on the capacity of liver and epiderm of adult and weanging RATs in transformation of Benzo (α) Pyrene.Materials and Methods: In a metabolic activiation assay system, cytochorome P-50 (from microsomal fraction) catalyses the formation of reactive epoxide of BaP which can then interact with exogenous DNA The capacity of cytochrome P-450 for BαP-DNA adducts formation from different organs are adult RAT live>>> adult RAT skin>> weanging RAT liver> weanling RAT skin. With the addition of cytosol (the source of GLUTATHIONE S transferase (GST) to the microsome-mediated system an In vitro detoxification model has been established.Results: The results obtained by the addition of different cytosolic samples are shown in several tables in the text. These data show that isolation of subcellular fractions from young RATs are less efficient in the biotransformation of BαP and detoxification by GSH is a passive process that depends on activation process. Also metabolic activation of BaP with cytochorome P-450 is not the first degree with GLUTATHIONE detoxification. However, the results obtined In vitro do not reflect the exact change In vivo.

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References

METABOLIC ACTIVATION AND DNA ADDUCT FORMATION OF BENZO (A) PYRENE BY ADULT AND NEWBORN RAT SKIN ANDLIVER MICROSOMES

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APA: Copy

MOHAMMADI QANATGHESTANI, M., ALAMEH, A.A.A., ASSADI, MH., & KHAGEH, M.R.. (2003). INHIBITION OF MICROSOME-MEDIATED BINDING OF BENZO (Α) PYRENE TO"DNA BY CYTOSOLIC REACTION FROM LIVER AND SKIN RATS IN CVITRO. JOURNAL OF IRANIAN ANATOMICAL SCIENCES, 1(4), 53-62. SID. https://sid.ir/paper/81421/en

Vancouver: Copy

MOHAMMADI QANATGHESTANI M., ALAMEH A.A.A., ASSADI MH., KHAGEH M.R.. INHIBITION OF MICROSOME-MEDIATED BINDING OF BENZO (Α) PYRENE TO"DNA BY CYTOSOLIC REACTION FROM LIVER AND SKIN RATS IN CVITRO. JOURNAL OF IRANIAN ANATOMICAL SCIENCES[Internet]. 2003;1(4):53-62. Available from: https://sid.ir/paper/81421/en

IEEE: Copy

M. MOHAMMADI QANATGHESTANI, A.A.A. ALAMEH, MH. ASSADI, and M.R. KHAGEH, “INHIBITION OF MICROSOME-MEDIATED BINDING OF BENZO (Α) PYRENE TO"DNA BY CYTOSOLIC REACTION FROM LIVER AND SKIN RATS IN CVITRO,” JOURNAL OF IRANIAN ANATOMICAL SCIENCES, vol. 1, no. 4, pp. 53–62, 2003, [Online]. Available: https://sid.ir/paper/81421/en

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