EFFECT OF DIFFERENT DOSES OF STAUROSPORINE FOR NEURONAL DIFFERENTIATION

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SADRI SOHEYL; DAVARI ZANJANI M.; AZADBAKHT MEHRI; AMINI ALI; AMIRI IRAJ

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Journal: Anatomical Sciences Journal Year:2007 | Volume:5 | Issue:19-20 Page(s): 157-166

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Title

EFFECT OF DIFFERENT DOSES OF STAUROSPORINE FOR NEURONAL DIFFERENTIATION

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Keywords

NEURONAL DIFFERENTIATIONQ3

STAUROSPORINEQ3

APOPTOSISQ2

PC-12Q3

Abstract

Purpose: The present study was designed to investigate the effect of different doses of STAUROSPORINE on differentiation of PC-12 cell line into differentiated neuronal cells. Materials and Methods: PC-12 cell line as a useful model system for neurobiological studies was maintained in RPMI 1640 supplemented with 10% FBS. STAUROSPORINE were added to culture medium in different concentrations (110, 214, 316 and 1000nM), then morphology and apoptotic index were assessed by total neurite length estimation and TUNEL staining.Results: Data showed that total neurite length of PC-12 cells that were treated with 110, 214, 316 and 1000nM was 44±9.3, 153±15.0, 104±10.4 and 31±9.6μm respectively. Therefore PC-12 cells that were treated with 214nM STAUROSPORINE had the greatest neurite length in compression with the other concentrations (P<0.05). In addition apoptotic index in these concentrations was 3±0.7,4±0.8,8±1.0 and 10±1.1 respectively, Therefore PC-12 cells that were treated with 110 and 214nM STAUROSPORINE had minimal apoptotic index (P<0.05).Conclusion: Finally it can be concluded that 214nM concentration of STAUROSPORINE is an optimum concentration for differentiation of neuronal cell lines to differentiated neuronal cells.

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APA: Copy

SADRI, SOHEYL, DAVARI ZANJANI, M., AZADBAKHT, MEHRI, AMINI, ALI, & AMIRI, IRAJ. (2007). EFFECT OF DIFFERENT DOSES OF STAUROSPORINE FOR NEURONAL DIFFERENTIATION. JOURNAL OF IRANIAN ANATOMICAL SCIENCES, 5(19-20), 157-166. SID. https://sid.ir/paper/81453/en

Vancouver: Copy

SADRI SOHEYL, DAVARI ZANJANI M., AZADBAKHT MEHRI, AMINI ALI, AMIRI IRAJ. EFFECT OF DIFFERENT DOSES OF STAUROSPORINE FOR NEURONAL DIFFERENTIATION. JOURNAL OF IRANIAN ANATOMICAL SCIENCES[Internet]. 2007;5(19-20):157-166. Available from: https://sid.ir/paper/81453/en

IEEE: Copy

SOHEYL SADRI, M. DAVARI ZANJANI, MEHRI AZADBAKHT, ALI AMINI, and IRAJ AMIRI, “EFFECT OF DIFFERENT DOSES OF STAUROSPORINE FOR NEURONAL DIFFERENTIATION,” JOURNAL OF IRANIAN ANATOMICAL SCIENCES, vol. 5, no. 19-20, pp. 157–166, 2007, [Online]. Available: https://sid.ir/paper/81453/en

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