NEUROPROTECTIVE EFFECT OF MITOCHONDRIAL KATP CHANNEL OPENER UPON NEURONAL CORTICAL BRAIN OF RAT POPULATION

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SOLEYMANI MANSOUREH; MAHDIZADEH MAHDI; BAKHSHAYESH M.; SOLEYMANI SARA; TABATABAEI PARVANEH

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Journal: Anatomical Sciences Journal Year:2007 | Volume:5 | Issue:18 Page(s): 1-8

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Title

NEUROPROTECTIVE EFFECT OF MITOCHONDRIAL KATP CHANNEL OPENER UPON NEURONAL CORTICAL BRAIN OF RAT POPULATION

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Keywords

K-ATP CHANNEL OPENERSQ3

ISCHEMIA REPERFUSION INJURYQ3

Abstract

Purpose: So far there is no effective drug therapy to prevent neuronal loss after brain stroke. In the present study we studied effects of The Mitochondrial K-ATP channel regulators on neuronal cell population and neurological function after ischemia reperfusion in the rat.Materials and Methods: Rats temporarily subjected to four vessels occlusion for 15 minutes followed by 24 hours reperfusion with or without K-ATP channel regulators. Neurological assessment was conducted after 24h reperfusion by consciousness scoring and motor function according to the methods reported by Lemay and Tarloe. After tissue processing and crysel violet staining total and normal cell number was assessed in parietal cortex.Data was analyzed by ANOVA software.Results: The normal cell count of neuronal population significantly increased in the K-ATP channel opener (Diazoxide) treated ischemia-reperfusion group compared with the control group. Cell count and neurological function scores were dependent to dose of K-ATP channel regulators in vivo.Conclusions: Our results showed that Diazoxide treatment leads to better preservation of cortical neurons in rat.

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APA: Copy

SOLEYMANI, MANSOUREH, MAHDIZADEH, MAHDI, BAKHSHAYESH, M., SOLEYMANI, SARA, & TABATABAEI, PARVANEH. (2007). NEUROPROTECTIVE EFFECT OF MITOCHONDRIAL KATP CHANNEL OPENER UPON NEURONAL CORTICAL BRAIN OF RAT POPULATION. JOURNAL OF IRANIAN ANATOMICAL SCIENCES, 5(18), 1-8. SID. https://sid.ir/paper/81480/en

Vancouver: Copy

SOLEYMANI MANSOUREH, MAHDIZADEH MAHDI, BAKHSHAYESH M., SOLEYMANI SARA, TABATABAEI PARVANEH. NEUROPROTECTIVE EFFECT OF MITOCHONDRIAL KATP CHANNEL OPENER UPON NEURONAL CORTICAL BRAIN OF RAT POPULATION. JOURNAL OF IRANIAN ANATOMICAL SCIENCES[Internet]. 2007;5(18):1-8. Available from: https://sid.ir/paper/81480/en

IEEE: Copy

MANSOUREH SOLEYMANI, MAHDI MAHDIZADEH, M. BAKHSHAYESH, SARA SOLEYMANI, and PARVANEH TABATABAEI, “NEUROPROTECTIVE EFFECT OF MITOCHONDRIAL KATP CHANNEL OPENER UPON NEURONAL CORTICAL BRAIN OF RAT POPULATION,” JOURNAL OF IRANIAN ANATOMICAL SCIENCES, vol. 5, no. 18, pp. 1–8, 2007, [Online]. Available: https://sid.ir/paper/81480/en

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