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Title

THE STUDY OF QUERCETIN EFFECTS ON BEHAVIORAL AND NIGROSTRIATAL TISSUE IN THE EXPERIMENTAL MODEL OF PARKINSON IN ADULT RAT

Pages

  225-239

Abstract

 Purpose: The aim of this study is investigating the effect of QUERCETIN on behavioral and nigrostriatal tissue in the experimental model of Parkinson in adult rat Materials and Methods: In this study we used 80 male rats from Wistar spring with body weight of 200-250 g. In order to make parkinson model, 6-OHDA (12.5 mg/kg) was injected intrastriatal unilaterally using stereotaxic method. Lesion rats were pretreated intraperitoneally with QUERCETIN (20 mg/kg) one hour before surgery and once a day with 10 & 20 mg/kg doses up to one month after surgery. Rotational behaviore of apomorphine-induced postlesion was measured during the fifth week after surgery considered as treatment efficiency indicator. SNC cells were studied with nissle staning method.Results: Behavioral tests in the fifth week revealed that Apomorphine caused evident contralateral rotation in lesion group (P<0.001) and very low rotation in treatment group (P<0.01) comparing with sham group. Treatment group showed decrease in numbers of rotation (P<0.01) comparing with lesion group. Treatment groups with 10 and 20 mg/kg QUERCETIN did not show significant differences statistically. The number of SNC neurons in left side showed significant reduction in lesion group (P<0.001) and treatment groups (P<0.01) comparing with right side, but did not show significant changes in sham group.Conclusion: Behavioral and structural results indicated short-term intra-peritoneal administration of QUERCETIN is effective as an ANTIOXIDANT in treatment of early PD and may enhance the survival of nigral dopaminergic neurons.

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    APA: Copy

    ARIANPOUR, R., JOGHATAEI, M.T., MAHDIZADEH, M., ROUGHANI, M., NOUBAKHT, M., ROUZ BEHI, A.A., & ASGARI, H.A.. (2006). THE STUDY OF QUERCETIN EFFECTS ON BEHAVIORAL AND NIGROSTRIATAL TISSUE IN THE EXPERIMENTAL MODEL OF PARKINSON IN ADULT RAT. JOURNAL OF IRANIAN ANATOMICAL SCIENCES, 4(3), 225-239. SID. https://sid.ir/paper/81582/en

    Vancouver: Copy

    ARIANPOUR R., JOGHATAEI M.T., MAHDIZADEH M., ROUGHANI M., NOUBAKHT M., ROUZ BEHI A.A., ASGARI H.A.. THE STUDY OF QUERCETIN EFFECTS ON BEHAVIORAL AND NIGROSTRIATAL TISSUE IN THE EXPERIMENTAL MODEL OF PARKINSON IN ADULT RAT. JOURNAL OF IRANIAN ANATOMICAL SCIENCES[Internet]. 2006;4(3):225-239. Available from: https://sid.ir/paper/81582/en

    IEEE: Copy

    R. ARIANPOUR, M.T. JOGHATAEI, M. MAHDIZADEH, M. ROUGHANI, M. NOUBAKHT, A.A. ROUZ BEHI, and H.A. ASGARI, “THE STUDY OF QUERCETIN EFFECTS ON BEHAVIORAL AND NIGROSTRIATAL TISSUE IN THE EXPERIMENTAL MODEL OF PARKINSON IN ADULT RAT,” JOURNAL OF IRANIAN ANATOMICAL SCIENCES, vol. 4, no. 3, pp. 225–239, 2006, [Online]. Available: https://sid.ir/paper/81582/en

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