Modeling Obstructive Sleep Apnea using Dynamical Phase Transition

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Raiesdana Somayeh

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF BIOMEDICAL ENGINEERING Year:2018 | Volume:12 | Issue:3 Page(s): 249-263

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Information Journal Paper

Title

Modeling Obstructive Sleep Apnea using Dynamical Phase Transition

Author(s)

Raiesdana Somayeh | Issue Writer Certificate

Keywords

sleep modelingQ1

dynamical phase transitionQ2

obstructive sleep apneaQ1

arousalQ1

hysteresisQ1

Abstract

Sleep is an essential process to maintain and improve human activities, while many details related to sleep are still not well understood. Decreased or fragmented sleep is a health risk that might result in heart disease or diabetes on one hand and degradation of consciousness and cognition on the other hand. Sleep fragmentation is a phenomenon in which an individual's sleep is intermittently disrupted by arousal caused by external factors (noise) or internal factors (apnea) although sleep deprivation does not completely occur. Computational modeling is a suitable framework for understanding complex biological mechanisms. In this paper, the fundamental phenomena underlying the sleep-wake transition was reviewed and simulated. The dynamical behavior of model was then investigated and afterwards the factors that might cause obstructive sleep apnea were implemented and evaluated. The model includes two main neuronal populations: the ascending arousal system in the brain stem that is responsible for awakening and a neuronal population in the hypothalamus, called VLPO, which mediates sleep. These populations have mutual inhibition on each other causing a ﬂ ip-ﬂ op or switching behavior between sleep and wake. The results of modeling in this paper showed hysteresis in the sleep-wake cycle, the size of which is affected by factors causing arousal. In OSA, intermittent and unstable transitions as well as the shrinking of bistable zone is expected. The model could reproduce some experimental results related to obstructive apneas.

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APA: Copy

Raiesdana, Somayeh. (2018). Modeling Obstructive Sleep Apnea using Dynamical Phase Transition. IRANIAN JOURNAL OF BIOMEDICAL ENGINEERING, 12(3 ), 249-263. SID. https://sid.ir/paper/81631/en

Vancouver: Copy

Raiesdana Somayeh. Modeling Obstructive Sleep Apnea using Dynamical Phase Transition. IRANIAN JOURNAL OF BIOMEDICAL ENGINEERING[Internet]. 2018;12(3 ):249-263. Available from: https://sid.ir/paper/81631/en

IEEE: Copy

Somayeh Raiesdana, “Modeling Obstructive Sleep Apnea using Dynamical Phase Transition,” IRANIAN JOURNAL OF BIOMEDICAL ENGINEERING, vol. 12, no. 3 , pp. 249–263, 2018, [Online]. Available: https://sid.ir/paper/81631/en

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