EFFECT OF HYDROALCOHOLIC EXTRACT OF AVENA SATIVA L. ON MORPHINE WITHDRAWAL SIGNS IN MALE MICE

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ABBASI MALEKI F.; ABBASI MALEKI S.; MOUSAVI S.Z.; KHAYATNOURI M.H.; NAJAFI GH.

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Journal: Journal of Sabzevar University of Medical Sciences Year:2014 | Volume:20 | Issue:4 Page(s): 408-415

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Title

EFFECT OF HYDROALCOHOLIC EXTRACT OF AVENA SATIVA L. ON MORPHINE WITHDRAWAL SIGNS IN MALE MICE

Author(s)

Keywords

AVENA SATIVA L.Q2

HYDROALCOHOLIC EXTRACTQ2

MORPHINEQ2

WITHDRAWAL SYNDROMEQ3

MICEQ2

Abstract

Background and Purpose: It showed that antidepressants may reduce the abuse potential of opioid. In other hand, studies showed avena sativa has antidepressant and sedative properties. So the aim of this study was to investigate the effect of ethanolic extract of Avena sativa on MORPHINE withdrawal signs in male MICE.Material and Methods: In this experimental studyforty male NMRI MICE (20-30 g) were randomly divided into 5 groups of 8: control groups received MORPHINE and normal saline (10ml/kg) and other groups received ethanol (3%) and different doses of ethanolic extractof Avena sativa (50,100 and 200mg/kg).Morphine dependency was induced using a four- day schedule method with 50, 50, 75 and 50mg/kg dosing respectively. In fourth day 2 hours after single dose of MORPHINE, naloxone was injected (5 mg /kg) and withdrawal signs were recorded with number of jumping and diarrhea, grooming, wet dog shake, teeth chattering, writing, climbing as scores of 0 to 3 during 30min.The data were expressed with one-way ANOVA for quantities and Mann-Whitney U test for qualities data’s and they were analyzed with SPSS 15 and P values less than 0.05 were considered significant.Results: The present study findings showed that all doses of ethanolic extract of Avena sativa compared to control group, significantly and dose- dependently decrease the number of jumping in MORPHINE dependent MICE (56.12±6.46, 40.0±5.33 and 31.5±2.5 respectively) P<0.05 and P<0.01 respectively).Grooming and teeth chattering also decreased with all doses of extract (P<0.05).Wet dog shakes, climbing and rearing significantly decreased only by high doses (200mg/kg) of extract. Diarrhea also decreased with 100 and 200 mg/kg of extract (P<0.05).Conclusion: Findings of present study showed that HYDROALCOHOLIC EXTRACT of avena sativa attenuate MORPHINE withdrawal signs. But, Further studies need to be carried out to better understanding of their mechanism.

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MORPHINE WITHDRAWAL SYMPTOMS IMPROVEMENT BY ZIZIPHORA TENUIOR L. ETHANOIC EXTRACT IN MALE MICE

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APA: Copy

ABBASI MALEKI, F., ABBASI MALEKI, S., MOUSAVI, S.Z., KHAYATNOURI, M.H., & NAJAFI, GH.. (2014). EFFECT OF HYDROALCOHOLIC EXTRACT OF AVENA SATIVA L. ON MORPHINE WITHDRAWAL SIGNS IN MALE MICE. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 20(4), 408-415. SID. https://sid.ir/paper/81770/en

Vancouver: Copy

ABBASI MALEKI F., ABBASI MALEKI S., MOUSAVI S.Z., KHAYATNOURI M.H., NAJAFI GH.. EFFECT OF HYDROALCOHOLIC EXTRACT OF AVENA SATIVA L. ON MORPHINE WITHDRAWAL SIGNS IN MALE MICE. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;20(4):408-415. Available from: https://sid.ir/paper/81770/en

IEEE: Copy

F. ABBASI MALEKI, S. ABBASI MALEKI, S.Z. MOUSAVI, M.H. KHAYATNOURI, and GH. NAJAFI, “EFFECT OF HYDROALCOHOLIC EXTRACT OF AVENA SATIVA L. ON MORPHINE WITHDRAWAL SIGNS IN MALE MICE,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 20, no. 4, pp. 408–415, 2014, [Online]. Available: https://sid.ir/paper/81770/en

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