EFFECTS OF SALVIGENIN, A FLAVONOIDS FROM SALVIA OFFICINAL IS, ON DIABETIC AND CARDIAC INDICES OF TYPE 1 DIABETIC RATS

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MOHAMMAD SADEGHI HAMID; VAHIDI ALIREZA; REZVANI MOHAMMAD EBRAHIM; ESMAEILI DEHAJ MANSOUR; ALIABADI ALI

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Journal: Journal of Sabzevar University of Medical Sciences Year:2016 | Volume:23 | Issue:2 Page(s): 281-289

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Title

EFFECTS OF SALVIGENIN, A FLAVONOIDS FROM SALVIA OFFICINAL IS, ON DIABETIC AND CARDIAC INDICES OF TYPE 1 DIABETIC RATS

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Keywords

DIABETESQ2

SALVIGENINQ1

GLYCOSYLATED HEMOGLOBINQ2

INSULINQ2

RATQ2

Abstract

Background: Flavonoids accounted for the most of antidiabetic effects of heral medicines. The effects of SALVIGENIN, a flavonoids from salvia officinalis, were not reported. We aimed to investigate the effects of the flavonoid on biochemical indices and cardiac hemodynamic parameters of type 1 diabetic RATs.Materials and Methods: After extracting the herb, SALVIGENIN was purified by extraction and silica gel column chromatography. Type 1 DIABETES was induced by single injection of streptozotocin (STZ) at dose of 70 mg/kg. The RATs were allocated into 4 groups as follows: control group that received vehicle and treatments groups that received SALVIGENIN at doses of 5, 10 or 25 mg/kg bodyweight for 30 days. Thereafter, blood samples were collected and fasting blood sugar, hemoglobin A1c, serum lipid profile and serum INSULIN level were measured. One way analysis of variances was used to assess significant differences between means of parameters between groups.Result: The obtained results implied that SALVIGENIN can significantly reduce fasting blood sugar, hemoglobin A1cand serum lipid profile. In addition, serum INSULIN level and plasma HDL were significantly elevated in RATs treated with SALVIGENIN in compared to control RATs.

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EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE IN INPATIENT CARE: TAKE A LOOK AT EUROPE

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APA: Copy

MOHAMMAD SADEGHI, HAMID, VAHIDI, ALIREZA, REZVANI, MOHAMMAD EBRAHIM, ESMAEILI DEHAJ, MANSOUR, & ALIABADI, ALI. (2016). EFFECTS OF SALVIGENIN, A FLAVONOIDS FROM SALVIA OFFICINAL IS, ON DIABETIC AND CARDIAC INDICES OF TYPE 1 DIABETIC RATS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 23(2), 281-289. SID. https://sid.ir/paper/81959/en

Vancouver: Copy

MOHAMMAD SADEGHI HAMID, VAHIDI ALIREZA, REZVANI MOHAMMAD EBRAHIM, ESMAEILI DEHAJ MANSOUR, ALIABADI ALI. EFFECTS OF SALVIGENIN, A FLAVONOIDS FROM SALVIA OFFICINAL IS, ON DIABETIC AND CARDIAC INDICES OF TYPE 1 DIABETIC RATS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;23(2):281-289. Available from: https://sid.ir/paper/81959/en

IEEE: Copy

HAMID MOHAMMAD SADEGHI, ALIREZA VAHIDI, MOHAMMAD EBRAHIM REZVANI, MANSOUR ESMAEILI DEHAJ, and ALI ALIABADI, “EFFECTS OF SALVIGENIN, A FLAVONOIDS FROM SALVIA OFFICINAL IS, ON DIABETIC AND CARDIAC INDICES OF TYPE 1 DIABETIC RATS,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 23, no. 2, pp. 281–289, 2016, [Online]. Available: https://sid.ir/paper/81959/en

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