EFFECT OF UMBELLIPRENIN ON BEHAVIORAL SYMPTOMS OF NEUROPATHIC PAIN IN CHRONIC CONSTRICTION INJURY MODEL (CCI) OF NEUROPATHY IN ADULT MALE RATS

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JAFARI FARANAK; GHOLAMI OMID; PEJHAN AKBAR; AMIN BAHAREH; NAZEMI SAMAD

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Journal: Journal of Sabzevar University of Medical Sciences Year:2018 | Volume:25 | Issue:4 Page(s): 547-554

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Title

EFFECT OF UMBELLIPRENIN ON BEHAVIORAL SYMPTOMS OF NEUROPATHIC PAIN IN CHRONIC CONSTRICTION INJURY MODEL (CCI) OF NEUROPATHY IN ADULT MALE RATS

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Keywords

ALLODYNIAQ2

HYPERALGESIAQ1

NEUROPATHIC PAINQ2

RATQ1

UMBELLIPRENINQ2

Abstract

Background and Aims: Chronic NEUROPATHIC PAIN caused by damage or disturbance of the functioning of the somatosensory system is one of the major health problems. The aim of this study was to investigate the effect of UMBELLIPRENIN (UMB) on the symptoms of NEUROPATHIC PAIN in chronic constriction injury model (CCI) of neuropathy in adult male RATs.Materials and Methods: 24 Wistar RATs (250±20 g) were randomly divided into three groups: sham, CCI and CCI+UMB (100 mg/rat) groups. UMB was injected intrathecaly one day before surgery, and three days after surgery. Von Frey and Hot-Plate tests were performed one day before surgery and on days 2, 4, 7, 10 and 14 after surgery. The results were reported as mean and SEM (p<0.05 was considered statistically significant).Results: The results of the von Frey and Hotplate test showed the development of mechanical ALLODYNIA and thermal HYPERALGESIA after chronic constriction of the sciatic nerve, in injured hind paw. Pre-emptive treatment of UMBELLIPRENIN with a dose of 100 mg/rat has been able to prevent the induction of ALLODYNIA and HYPERALGESIA (p<0.05). This effect was more prominence in preventing of HYPERALGESIA.Conclusion: Pre-emptive Intrathecal injection of UMBELLIPRENIN could prevent the development of behavioral symptoms of NEUROPATHIC PAIN in RATs. This effect is probably due to the anti-inflammatory effect of UMBELLIPRENIN.

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APA: Copy

JAFARI, FARANAK, GHOLAMI, OMID, PEJHAN, AKBAR, AMIN, BAHAREH, & NAZEMI, SAMAD. (2018). EFFECT OF UMBELLIPRENIN ON BEHAVIORAL SYMPTOMS OF NEUROPATHIC PAIN IN CHRONIC CONSTRICTION INJURY MODEL (CCI) OF NEUROPATHY IN ADULT MALE RATS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 25(4 ), 547-554. SID. https://sid.ir/paper/82117/en

Vancouver: Copy

JAFARI FARANAK, GHOLAMI OMID, PEJHAN AKBAR, AMIN BAHAREH, NAZEMI SAMAD. EFFECT OF UMBELLIPRENIN ON BEHAVIORAL SYMPTOMS OF NEUROPATHIC PAIN IN CHRONIC CONSTRICTION INJURY MODEL (CCI) OF NEUROPATHY IN ADULT MALE RATS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;25(4 ):547-554. Available from: https://sid.ir/paper/82117/en

IEEE: Copy

FARANAK JAFARI, OMID GHOLAMI, AKBAR PEJHAN, BAHAREH AMIN, and SAMAD NAZEMI, “EFFECT OF UMBELLIPRENIN ON BEHAVIORAL SYMPTOMS OF NEUROPATHIC PAIN IN CHRONIC CONSTRICTION INJURY MODEL (CCI) OF NEUROPATHY IN ADULT MALE RATS,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 4 , pp. 547–554, 2018, [Online]. Available: https://sid.ir/paper/82117/en

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