STUDY OF THE ROLE OF A2A ADENOSINE RECEPTORS IN CONVULSIONS INDUCED BY THE PERFORANT PATH KINDLING OF HIPPOCAMPUS IN RAT

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MOHAMMADZADEH MOHAMMAD; MIRNAJAFIZADEH S.J.

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Journal: Journal of Sabzevar University of Medical Sciences Year:2008 | Volume:15 | Issue:3 (49) Page(s): 129-137

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Title

STUDY OF THE ROLE OF A2A ADENOSINE RECEPTORS IN CONVULSIONS INDUCED BY THE PERFORANT PATH KINDLING OF HIPPOCAMPUS IN RAT

Author(s)

MOHAMMADZADEH MOHAMMAD | MIRNAJAFIZADEH S.J. | Issue Writer Certificate

Keywords

KINDLINGQ2

CONVULSIONQ3

ADENOSINEQ3

PERFORANT PATHQ3

Abstract

Background and Purpose: Previous studies have not properly clarified the role of A2A ADENOSINE receptors in CONVULSIONs induced by KINDLING. In the present study, the role of these receptors in CONVULSIONs induced PERFORANT PATH KINDLING has been investigated by blocking these receptors (with specific antagonists).Methods and Materials: This experimental study was conducted on 24 rats which were randomly divided into four groups of six. They were kindled by electric stimulation of the PERFORANT PATH. In two groups, before each KINDLING stimulation, antagonists of A2A ADENOSINE receptors (ZM 241385) (500 and 200 mM) was injected to the lateral ventricle of the rats. Control animals were given only the electric stimulations. In the fourth group (sham), the solvent of the abovementioned drug was injected to the lateral ventricle before KINDLING stimulations. The obtained data were analyzed using two-way ANOVA and Tukey tests.Results: Injecting the antagonists of A2A ADENOSINE receptors (ZM 241385) (500 mM) to the lateral ventricle of the rats postponed the process of KINDLING. Two-way ANOVA indicated that number of stimulations required to reach the convulsive stages were significantly increased (P<o.oo1, F(4, 40) = 47). Also, compared with the sham group which received the solvent of the drug, a significant reduction was observed in the duration of depletion waves following accumulation (P<0.05, F(6, 60) = 2.5) in this group.Conclusion: According to the findings, injecting the antagonists of A2A ADENOSINE receptors produces a significant anticonvulsant effect on the CONVULSIONs induced by PERFORANT PATH KINDLING, and that this effect functions through controlling the effect of endogenic ADENOSINE on A2A ADENOSINE receptors.

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APA: Copy

MOHAMMADZADEH, MOHAMMAD, & MIRNAJAFIZADEH, S.J.. (2008). STUDY OF THE ROLE OF A2A ADENOSINE RECEPTORS IN CONVULSIONS INDUCED BY THE PERFORANT PATH KINDLING OF HIPPOCAMPUS IN RAT. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 15(3 (49)), 129-137. SID. https://sid.ir/paper/82181/en

Vancouver: Copy

MOHAMMADZADEH MOHAMMAD, MIRNAJAFIZADEH S.J.. STUDY OF THE ROLE OF A2A ADENOSINE RECEPTORS IN CONVULSIONS INDUCED BY THE PERFORANT PATH KINDLING OF HIPPOCAMPUS IN RAT. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2008;15(3 (49)):129-137. Available from: https://sid.ir/paper/82181/en

IEEE: Copy

MOHAMMAD MOHAMMADZADEH, and S.J. MIRNAJAFIZADEH, “STUDY OF THE ROLE OF A2A ADENOSINE RECEPTORS IN CONVULSIONS INDUCED BY THE PERFORANT PATH KINDLING OF HIPPOCAMPUS IN RAT,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 15, no. 3 (49), pp. 129–137, 2008, [Online]. Available: https://sid.ir/paper/82181/en

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