IMMUNOTHERAPY IN 1200 MORPHINE ADDICT IN IRAN WITH MORPHINE VACCINE

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AKBARZADEH A.; NOVROZIAN D.; AFSHAR P.; FARAHMAND B.; VAEZ J.; FARHANGI A.

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Journal: Journal of Sabzevar University of Medical Sciences Year:2003 | Volume:10 | Issue:3 (29) Page(s): 6-22

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Information Journal Paper

Title

IMMUNOTHERAPY IN 1200 MORPHINE ADDICT IN IRAN WITH MORPHINE VACCINE

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Keywords

MORPHINE VACCINEQ4

REWARD SYSTEMQ4

IMMUNOTHERAPYQ2

Abstract

Newly developed compound derived from the immune system help combat morphine abuse by destroying the drug soon after it enters the bloodstream. A morphine-6-succinyI-SA (M-6-S-SA) vaccine was designed in an effort to obtain a potent, long - lasting anti-morphine immune response for the treatment of morphine abuse. The analogue incorporated a succinic anhydride linker moiety in place of hydroxy group at c-6 of the morphine framework. Then morphine 6-hemi-succinate was conjugated to serum albumin (SA) in aqueous solution in the presence of tributylamin, isobutylchlorformate and dioxan. M-6-S-SA was synthesized in three chemical steps starting from morphine sulphate and the extent of conjugation was determined by base hydrolysis of the conjugate, extraction and measurement of free morphine or with U. V absorbance. An average of 6.5 molecules of morphine were conjugated to each molecule of protein 1200 morphine addictions from separate areas of Iran vaccinated with suitable doses in 3 steps for each addiction. After vaccination 95% of addictions immunized with three doses of the vaccine, were found to be producing antibody in 60 days later as determined by Electrophoresis method, which measures binding antigen by antibody with western blotting ELISA and TLC over layer. Necrosis, fever, shock, etc in all steps and with whole volunteers. Finally the MORPHINE VACCINE also recommends for prevention of morphine addiction because we obtained very good results with 100% immune and clinical response. We also found that, there would be no cross- reaction between these antibody and analgesic drugs.

Cites

SAFETY AND IMMUNOGENECITY OF HUMAN THERAPEUTIC MORPHINE VACCINE IN MORPHINE ADDICTS

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APA: Copy

AKBARZADEH, A., NOVROZIAN, D., AFSHAR, P., FARAHMAND, B., VAEZ, J., & FARHANGI, A.. (2003). IMMUNOTHERAPY IN 1200 MORPHINE ADDICT IN IRAN WITH MORPHINE VACCINE. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 10(3 (29)), 6-22. SID. https://sid.ir/paper/82213/en

Vancouver: Copy

AKBARZADEH A., NOVROZIAN D., AFSHAR P., FARAHMAND B., VAEZ J., FARHANGI A.. IMMUNOTHERAPY IN 1200 MORPHINE ADDICT IN IRAN WITH MORPHINE VACCINE. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2003;10(3 (29)):6-22. Available from: https://sid.ir/paper/82213/en

IEEE: Copy

A. AKBARZADEH, D. NOVROZIAN, P. AFSHAR, B. FARAHMAND, J. VAEZ, and A. FARHANGI, “IMMUNOTHERAPY IN 1200 MORPHINE ADDICT IN IRAN WITH MORPHINE VACCINE,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 10, no. 3 (29), pp. 6–22, 2003, [Online]. Available: https://sid.ir/paper/82213/en

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