THE EFFECT OF HYPERTONIC AND HYPERONCOTIC SOLUTIONS IN THE RESUSCITATION OF HEMORRHAGIC SHOCKS IN FASTING RATS

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NEMATBAKHSH MAHDI; ASHRAFI F.; SAMARIAN S.H.

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Journal: Journal of Sabzevar University of Medical Sciences Year:2000 | Volume:7 | Issue:3 (17) Page(s): 10-21

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Information Journal Paper

Title

THE EFFECT OF HYPERTONIC AND HYPERONCOTIC SOLUTIONS IN THE RESUSCITATION OF HEMORRHAGIC SHOCKS IN FASTING RATS

Author(s)

NEMATBAKHSH MAHDI | ASHRAFI F. | SAMARIAN S.H. | Issue Writer Certificate

Keywords

HEMORRHAGIC SHOCKQ4

HYPERTONICQ3

HYPERTONIC-HYPERONCOTICQ4

ISOTONICQ4

FASTINGQ4

Abstract

In this today, we studied the therapeutic effect of HYPERTONIC and HYPERTONIC-hyperoncotic solutions on the resuscitation of controlled HEMORRHAGIC SHOCK in a FASTING scheme. 42 rats were randomly assigned into two groups: a control and a FASTING group. FASTING scheme consisted of periodic (12h) food and water deprivation. Then all animals were anaesthetized and were made to hemorrhage untill their mean blood pressure reached 40-50 mmHg which were maintained for 30 minutes. Then animals in each group were resuscitated with either (1) 4 cc/kg 5% NaCl or (2) 22 cc/kg normal saline or (3) 4 cc/kg 20% NaCl 3:1 v/v and 20% serum albumin or (4) 4 cc/kg normal saline. All animals were monitored for 1h after the infusion. Bp, serum electrolytes, osmolality and hematocrite were measured before hemorrhage and after resuscitation in each group and subgroup. Finally, all animals were sacrificed and their brain water content was measured. There were no significant differences in Bp, pulse rate, weight and serum electrolytes before the haemorrhagic shock between the two groups. Serum Osmolality 1h after resuscitation was significantly different among the subgroups of the control group. Other variables Ih after resuscitation had no significant difference among the 4 subgroups of the control and FASTING gaups. Also, no significant differences were observed as for Bp, pulse rate, serum osmolality, electrolytes and brain water content between similar subgroups in two groups.

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APA: Copy

NEMATBAKHSH, MAHDI, ASHRAFI, F., & SAMARIAN, S.H.. (2000). THE EFFECT OF HYPERTONIC AND HYPERONCOTIC SOLUTIONS IN THE RESUSCITATION OF HEMORRHAGIC SHOCKS IN FASTING RATS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 7(3 (17)), 10-21. SID. https://sid.ir/paper/82223/en

Vancouver: Copy

NEMATBAKHSH MAHDI, ASHRAFI F., SAMARIAN S.H.. THE EFFECT OF HYPERTONIC AND HYPERONCOTIC SOLUTIONS IN THE RESUSCITATION OF HEMORRHAGIC SHOCKS IN FASTING RATS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2000;7(3 (17)):10-21. Available from: https://sid.ir/paper/82223/en

IEEE: Copy

MAHDI NEMATBAKHSH, F. ASHRAFI, and S.H. SAMARIAN, “THE EFFECT OF HYPERTONIC AND HYPERONCOTIC SOLUTIONS IN THE RESUSCITATION OF HEMORRHAGIC SHOCKS IN FASTING RATS,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 7, no. 3 (17), pp. 10–21, 2000, [Online]. Available: https://sid.ir/paper/82223/en

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