EFFECT OF REGULAR RESISTANCE EXERCISE ON C-PEPTIDE VASCULAR FUNCTION IN DIABETIC RATS

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ZARINKALAM IBRAHIM; HEIDARIANPOUR ALI

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Paper Information

Journal: Journal of Sabzevar University of Medical Sciences Year:2013 | Volume:20 | Issue:1 (67) Page(s): 34-41

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Information Journal Paper

Title

EFFECT OF REGULAR RESISTANCE EXERCISE ON C-PEPTIDE VASCULAR FUNCTION IN DIABETIC RATS

Author(s)

ZARINKALAM IBRAHIM | HEIDARIANPOUR ALI | Issue Writer Certificate

Keywords

C-PEPTIDEQ2

SKIN BLOOD FLOWQ2

DIABETESQ2

EXERCISE TRAININGQ2

NITRIC OXIDE PATHWAYQ2

Abstract

Background: Many evidence showed that EXERCISE TRAINING has beneficial effects on SKIN BLOOD FLOW in the health and diabetic condition. On the other hand some finding showed that C-PEPTIDE has protective and therapeutic effect on vascular dysfunctioninduced by DIABETES. Therefore the purpose of this study is effects of resistance exercise on vascular function of C-PEPTIDE.Material and method: In this experimental study, Male wistar rats (220±10g, N=30) were used in two diabetic (control and trained) and one age-matched healthy control groups. After 1 week of DIABETES induction, animals were submitted to resistance EXERCISE TRAINING for 9 Weeks on ladder. To characterize cutaneous micro vascular responses by Laser Doppler flowmetery, animals were deeply anesthetized by intraperitoneal injection of pentobarbital sodium (50 mg/kg). For data analysis, one-way ANOVA test was used to compare the groups. Statistically significant difference between the minimum acceptable levels is p<0.05.Results: Local microinjection of C-PEPTIDE increased coetaneous blood flow in trained and control diabetic rats, however this effect in trained group is higher than control diabetic group rats. Administration of Nw-nitro-L-arginine (nitric oxide synthase inhibitor) before C-PEPTIDE reduced significantly C-PEPTIDE vascular effects in trained and control diabetic rats.Conclusions: Chronic resistance exercise potentiate C-PEPTIDE vascular function, possibly by NITRIC OXIDE PATHWAY.

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APA: Copy

ZARINKALAM, IBRAHIM, & HEIDARIANPOUR, ALI. (2013). EFFECT OF REGULAR RESISTANCE EXERCISE ON C-PEPTIDE VASCULAR FUNCTION IN DIABETIC RATS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 20(1 (67)), 34-41. SID. https://sid.ir/paper/82260/en

Vancouver: Copy

ZARINKALAM IBRAHIM, HEIDARIANPOUR ALI. EFFECT OF REGULAR RESISTANCE EXERCISE ON C-PEPTIDE VASCULAR FUNCTION IN DIABETIC RATS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2013;20(1 (67)):34-41. Available from: https://sid.ir/paper/82260/en

IEEE: Copy

IBRAHIM ZARINKALAM, and ALI HEIDARIANPOUR, “EFFECT OF REGULAR RESISTANCE EXERCISE ON C-PEPTIDE VASCULAR FUNCTION IN DIABETIC RATS,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 20, no. 1 (67), pp. 34–41, 2013, [Online]. Available: https://sid.ir/paper/82260/en

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