NON CHANGE OF MEF2C GENE EXPRESSION OF RATS LEFT VENTRICLE DUE TO ENDURANCE ACTIVITY

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FATHI MOHAMMAD

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Journal: Journal of Sabzevar University of Medical Sciences Year:2018 | Volume:24 | Issue:6 Page(s): 45-51

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Information Journal Paper

Title

NON CHANGE OF MEF2C GENE EXPRESSION OF RATS LEFT VENTRICLE DUE TO ENDURANCE ACTIVITY

Author(s)

FATHI MOHAMMAD | Issue Writer Certificate

Keywords

ENDURANCE ACTIVITYQ2

LEFT VENTRICLEQ1

MEF2C GENEQ1

MUSCULAR HEARTQ1

Abstract

Background & Objectives: MEF2C GENE induces slow twitch fibers in skeletal muscles which involves in various cellular processes. ENDURANCE ACTIVITY effects on expression of this genein skeletal muscle. The aim of this study was to investigate the effect of a course of ENDURANCE ACTIVITY onMef2c expression in cardiac.Materials & Methods: In this experimental research, 14 rats under controlled conditions (temperature, light/dark (12: 12) cycle, with ad Libitum access to food and water) were housed and randomly were divided into control and experimental groups after familiarization to ENDURANCE ACTIVITY protocol. The experimental group performed 14 weeks ENDURANCE ACTIVITY on motorized treadmill. They were anesthetized and sacrificed after 48 hours from the end of the last session of ENDURANCE ACTIVITY. The heart and LEFT VENTRICLE of rats were removed. Using real time PCR, the expression levels ofMef2c gene was determined. The data were analyzed by t-test.Results: ENDURANCE ACTIVITY induces the increase of MEF2C GENE expression in heart but it was not significant (p=0.148) in experimental group compared with control group.Conclusion: The endurance training possibly does not effect on induction of slow twitch and increasing of them in heart muscle. Therefore, there are unknown mechanisms attempt that the rate ofMef2c gene expression do not much change, to maintain optimal conditions of heart tissue.

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APA: Copy

FATHI, MOHAMMAD. (2018). NON CHANGE OF MEF2C GENE EXPRESSION OF RATS LEFT VENTRICLE DUE TO ENDURANCE ACTIVITY. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 24(6 ), 45-51. SID. https://sid.ir/paper/82274/en

Vancouver: Copy

FATHI MOHAMMAD. NON CHANGE OF MEF2C GENE EXPRESSION OF RATS LEFT VENTRICLE DUE TO ENDURANCE ACTIVITY. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;24(6 ):45-51. Available from: https://sid.ir/paper/82274/en

IEEE: Copy

MOHAMMAD FATHI, “NON CHANGE OF MEF2C GENE EXPRESSION OF RATS LEFT VENTRICLE DUE TO ENDURANCE ACTIVITY,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 6 , pp. 45–51, 2018, [Online]. Available: https://sid.ir/paper/82274/en

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