THE EFFECT OF GABA-A RECEPTORS IN THE REGULATION OF BLOOD CLUCOSE CONCENTRATION IN MICE

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GHERAVANI Z.; POURGHOLAMI M.H.

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Journal: Journal of Sabzevar University of Medical Sciences Year:2000 | Volume:7 | Issue:1 (15) Page(s): 36-44

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Title

THE EFFECT OF GABA-A RECEPTORS IN THE REGULATION OF BLOOD CLUCOSE CONCENTRATION IN MICE

Author(s)

GHERAVANI Z. | POURGHOLAMI M.H. | Issue Writer Certificate

Keywords

GABA-A RECEPTORSQ4

BLOOD GLUCOSE REGULATIONQ3

Abstract

The regulation of glucose concentration in blood is one of the complex phenomena which is affected by several hormonal and neural factors. The endocrine part of pancreas, the internal part of adrenal gland and liver has important roles in the regulation of blood glucose. Insulin, glucagon and somatostatine are just a few of the hormones that participate in the regulation of blood glucose. In addition to the hormonal agents, neurotransmitters, such as GABA-A, also play some role in the homeostasis of blood glucose. In this study, we used male Albino mice, each weighing 20-25 grams. This was done using GABA agonists and antagonists. Serial blood collection from each animal was done by retro orbital Sinus puncture, and glucose concentration.was measured using O-toluidine. In this experiment, the effect of different doses of a certain drug on blood glucose was studied, and average changes in blood glucose concentration were calculated each time. One-way ANOVA and t-test were adopted in the statistical analysis of the collected data. The results indicated that intracerebellar ventricle (ICV) injection of both bicuculine or picrotoxin caused a significant increase in the concentration of blood glucose while ICV injection of muscimol leads to a significant reduction in the blood glucose concentration. Therefore, it seems that GABA-A RECEPTORS might cause a reduction in the concentration of blood glucose, increasing the insulin plasma and decreasing the glucagons and somatostatine.On the whole, it can be said that GABA-A RECEPTORS have a controlling role in the reduction of blood glucose. Further research seems inevitable since the effect of GABA-A RECEPTORS on blood glucose concentration is a complex phenomenon.

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APA: Copy

GHERAVANI, Z., & POURGHOLAMI, M.H.. (2000). THE EFFECT OF GABA-A RECEPTORS IN THE REGULATION OF BLOOD CLUCOSE CONCENTRATION IN MICE. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 7(1 (15)), 36-44. SID. https://sid.ir/paper/82473/en

Vancouver: Copy

GHERAVANI Z., POURGHOLAMI M.H.. THE EFFECT OF GABA-A RECEPTORS IN THE REGULATION OF BLOOD CLUCOSE CONCENTRATION IN MICE. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2000;7(1 (15)):36-44. Available from: https://sid.ir/paper/82473/en

IEEE: Copy

Z. GHERAVANI, and M.H. POURGHOLAMI, “THE EFFECT OF GABA-A RECEPTORS IN THE REGULATION OF BLOOD CLUCOSE CONCENTRATION IN MICE,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 7, no. 1 (15), pp. 36–44, 2000, [Online]. Available: https://sid.ir/paper/82473/en

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