THE EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF HYOSCYAMUS NIGER SEEDS ON LEARNING AND SHORT-TERM MEMORY IN BALB/C MICE

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HOJJATI M.R.; TAJI F.; RAFIEIAN M.

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Journal: Journal of Sabzevar University of Medical Sciences Year:2012 | Volume:19 | Issue:3 (65) Page(s): 258-266

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Title

THE EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF HYOSCYAMUS NIGER SEEDS ON LEARNING AND SHORT-TERM MEMORY IN BALB/C MICE

Author(s)

HOJJATI M.R. | TAJI F. | RAFIEIAN M. | Issue Writer Certificate

Keywords

HYOSCYAMUS NIGERQ2

LEARNINGQ2

MEMORYQ2

WATER MAZEQ2

HYDRO-ALCOHOLIC EXTRACTQ2

MICEQ2

Abstract

Background: HYOSCYAMUS NIGER has many different therapeutic effects, such as anti-convulsive and sedative effects. In this study, we tried to evaluate the eventual effect of HYDRO-ALCOHOLIC EXTRACT of HYOSCYAMUS NIGER on spatial LEARNING and MEMORY in MICE using Morris WATER MAZE task.Materials and methods: In this study, 23 MICE were randomly divided into one control group and two experimental groups. The control group received normal saline and the experimental groups received HYDRO-ALCOHOLIC EXTRACTs of HYOSCYAMUS NIGER (1 or 2 mg/kg, i.p.). At first, saline or extracts were injected daily (7 days) and then spatial LEARNING was evaluated for 5 consecutive days. For evaluating short-term MEMORY, two probe-trial experiments were performed. Finally, data were analyzed using one-way ANOVA, followed by Tukey’s test.Results: Results obtained from day 3 and day 4 of the LEARNING period showed a significant reduction in LEARNING the WATER MAZE task in the experimental group (2 mg/kg) compared with the control group (p<0.05). In addition, probe-trial experiments demonstrated that HYOSCYAMUS NIGER (1 and 2 mg/kg) prevented formation of short-term MEMORY, while control animals succeeded to make short-term MEMORY.Conclusion: HYDRO-ALCOHOLIC EXTRACT of HYOSCYAMUS NIGER decreases the LEARNING of the WATER MAZE task and also disturbs short-term MEMORY.

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APA: Copy

HOJJATI, M.R., TAJI, F., & RAFIEIAN, M.. (2012). THE EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF HYOSCYAMUS NIGER SEEDS ON LEARNING AND SHORT-TERM MEMORY IN BALB/C MICE. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 19(3 (65)), 258-266. SID. https://sid.ir/paper/82637/en

Vancouver: Copy

HOJJATI M.R., TAJI F., RAFIEIAN M.. THE EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF HYOSCYAMUS NIGER SEEDS ON LEARNING AND SHORT-TERM MEMORY IN BALB/C MICE. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;19(3 (65)):258-266. Available from: https://sid.ir/paper/82637/en

IEEE: Copy

M.R. HOJJATI, F. TAJI, and M. RAFIEIAN, “THE EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF HYOSCYAMUS NIGER SEEDS ON LEARNING AND SHORT-TERM MEMORY IN BALB/C MICE,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 19, no. 3 (65), pp. 258–266, 2012, [Online]. Available: https://sid.ir/paper/82637/en

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