THE EFFECTS OF MORPHINE SENSITIZATION ON MORPHINE-STATE-DEPENDENT LEARNING

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ZARINDAST M.R.; REZAYOF A.

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Journal: ADVANCES IN COGNITIVE SCIENCE Year:2002 | Volume:4 | Issue:3 Page(s): 1-11

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Title

THE EFFECTS OF MORPHINE SENSITIZATION ON MORPHINE-STATE-DEPENDENT LEARNING

Author(s)

ZARINDAST M.R. | REZAYOF A. | Issue Writer Certificate

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Abstract

In the present study, the effects of morphine sensitization on morphine-induced impairment of memory formation and the state-dependent retrieval of a passive avoidance task learned under morphine influence have been investigated in mice. Pre-training administration of morphine (0.5, 2.5 and 5mg/kg) dose dependently suppressed the learning of one-trial passive avoidance task. Pre-test administration of morphine (0.5, 2.5 and 5 mg/kg) induced state-dependent retrieval of the memory acquired under pretrainign morphine influence. The inhibitory effect of morphine (5 mg/kg) on memory formation was significantly antagonized by pretreatment administation of naloxone (0.025, 0.5 and 1 mg/kg) before .the pre-training morphine. The pre-test administration of naloxone dose dependently inhibited the restoration induced by morphine (5 mg/kg). Amnesia induced by pre-training morphine significantly was inhibited in morphine-sensitized mice, which had previously received once daily injections of morphine (20 and 30 mg/kg, s.c.) for 3 days. Morphine sensitization did not affect on morphine state-dependent memory of passive avoidance. The inhibition of morphine-induced amnesia in morphine-sensitized mice was suppressed by one daily injections of naloxone (0.5, 1 and 2 mg/kg) 30 min prior to s.c. injections of morphine (20 mg/kg/day × 3 days). These results suggest that morphine sensitization affect the impairment of memory formation, but not the facilitation of retrieval induced by morphine.

Cites

THE INHIBITORY EFFECT OF VTA CHOLINERGIC RECEPTORS ON MORPHINE STATE DEPENDENT MEMORY IN RAT

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APA: Copy

ZARINDAST, M.R., & REZAYOF, A.. (2002). THE EFFECTS OF MORPHINE SENSITIZATION ON MORPHINE-STATE-DEPENDENT LEARNING. ADVANCES IN COGNITIVE SCIENCE, 4(3), 1-11. SID. https://sid.ir/paper/83046/en

Vancouver: Copy

ZARINDAST M.R., REZAYOF A.. THE EFFECTS OF MORPHINE SENSITIZATION ON MORPHINE-STATE-DEPENDENT LEARNING. ADVANCES IN COGNITIVE SCIENCE[Internet]. 2002;4(3):1-11. Available from: https://sid.ir/paper/83046/en

IEEE: Copy

M.R. ZARINDAST, and A. REZAYOF, “THE EFFECTS OF MORPHINE SENSITIZATION ON MORPHINE-STATE-DEPENDENT LEARNING,” ADVANCES IN COGNITIVE SCIENCE, vol. 4, no. 3, pp. 1–11, 2002, [Online]. Available: https://sid.ir/paper/83046/en

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