THE EFFECTS OF DIETARY OMEGA-3 FATTY ACID SUPPLEMENTATION ON INFLAMMATORY BIOMARKERS IN TYPE-2 DIABETIC PATIENTS

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MALEKSHAHI MOGHADAM A.; SAEDISOMEOLIA A.; DJALALI M.; SOJOUDI F.

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Journal: JOURNAL OF SCHOOL OF PUBLIC HEALTH AND INSTITUTE OF PUBLIC HEALTH RESEARCH Year:2011 | Volume:9 | Issue:3 Page(s): 73-81

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Title

THE EFFECTS OF DIETARY OMEGA-3 FATTY ACID SUPPLEMENTATION ON INFLAMMATORY BIOMARKERS IN TYPE-2 DIABETIC PATIENTS

Author(s)

MALEKSHAHI MOGHADAM A. | SAEDISOMEOLIA A. | DJALALI M. | SOJOUDI F. | Issue Writer Certificate

Keywords

OMEGA-3 FATTY ACIDQ3

TYPE-2 DIABETESQ2

CRPQ3

TNF-αQ3

IL-2Q3

Abstract

Background and Aim: OMEGA-3 FATTY ACIDs can reduce inflammation in diabetic patients via special mechanisms. The objective the current study was to investigate the effects dietary OMEGA-3 FATTY ACID supplementation on the serum levels of C-reactive protein (CRP), interleukin-2 (IL-2), and tumor necrosis factor-alpha (TNF-a) in type 2 diabetes patients.Materials and Methods: This randomized double-blind placebo-controlled clinical trial was conducted on 57 subjects with TYPE-2 DIABETES. The participants were randomly assigned to one of 2 groups receiving either an OMEGA-3 FATTY ACID supplement (containing 1584 mg eicosapentaenoic acid, 828 mg docosahexaenoic acid, and 338 mg other OMEGA-3 FATTY ACIDs) or a placebo tablet (containing 2100 mg sunflower oil) for a period of 8 weeks.Results: The serum TNF-a and IL-2 concentrations decreased significantly in the OMEGA-3 FATTY ACID group in comparison with the placebo group (in both cases, p<0.01). The intervention did not bring about any statistically significant changes in the serum CRP concentrations.Conclusion: Considering the beneficial effects of omega-3 dietary fatty acid supplements on the 2 inflammatory biomarkers, namely TNF-a and IL-2, TYPE-2 DIABETES patients are recommended to consume such supplements or foodstuffs rich in OMEGA-3 FATTY ACIDs, e.g., fish.

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APA: Copy

MALEKSHAHI MOGHADAM, A., SAEDISOMEOLIA, A., DJALALI, M., & SOJOUDI, F.. (2011). THE EFFECTS OF DIETARY OMEGA-3 FATTY ACID SUPPLEMENTATION ON INFLAMMATORY BIOMARKERS IN TYPE-2 DIABETIC PATIENTS. JOURNAL OF SCHOOL OF PUBLIC HEALTH AND INSTITUTE OF PUBLIC HEALTH RESEARCH, 9(3), 73-81. SID. https://sid.ir/paper/84878/en

Vancouver: Copy

MALEKSHAHI MOGHADAM A., SAEDISOMEOLIA A., DJALALI M., SOJOUDI F.. THE EFFECTS OF DIETARY OMEGA-3 FATTY ACID SUPPLEMENTATION ON INFLAMMATORY BIOMARKERS IN TYPE-2 DIABETIC PATIENTS. JOURNAL OF SCHOOL OF PUBLIC HEALTH AND INSTITUTE OF PUBLIC HEALTH RESEARCH[Internet]. 2011;9(3):73-81. Available from: https://sid.ir/paper/84878/en

IEEE: Copy

A. MALEKSHAHI MOGHADAM, A. SAEDISOMEOLIA, M. DJALALI, and F. SOJOUDI, “THE EFFECTS OF DIETARY OMEGA-3 FATTY ACID SUPPLEMENTATION ON INFLAMMATORY BIOMARKERS IN TYPE-2 DIABETIC PATIENTS,” JOURNAL OF SCHOOL OF PUBLIC HEALTH AND INSTITUTE OF PUBLIC HEALTH RESEARCH, vol. 9, no. 3, pp. 73–81, 2011, [Online]. Available: https://sid.ir/paper/84878/en

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