Prediction of mechanical strength of distal femur following GCT surgery using quantitative computed tomography based finite element method

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Rouhi Gholamreza; GHOUCHANI AZADEH; EBRAHIMZADEH MOHAMAD HOSEIN

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Journal: IRANIAN JOURNAL OF ORTHOPAEDIC SURGERY Year:2018 | Volume:16 | Issue:3 (62) Page(s): 243-250

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Title

Prediction of mechanical strength of distal femur following GCT surgery using quantitative computed tomography based finite element method

Author(s)

Rouhi Gholamreza | GHOUCHANI AZADEH | EBRAHIMZADEH MOHAMAD HOSEIN | Issue Writer Certificate

Keywords

Quantitative Computed Tomography (QCT)Q1

Finite Element MethodQ1

Distal Femur StrengthQ1

Giant Cell TumorQ1

In-Vitro Mechanical TestQ1

Abstract

Background: Distal femur is the most frequently affected site by Giant Cell Tumor (GCT). Surgery including tumor curettage and defect reconstruction with bone cement is a widely-used treatment. While post-operative fracture is a common complication, no criteria and/or biomechanical data are available to identify patients at high risk of fracture. Methods and materials: Since there is a strong correlation between bone strength and its fracture risk, in this study, bone strength following GCT surgery was predicted using quantitative computed tomography (QCT)-based Finite Element Method (FEM). Mechanical properties of bone-cement interface, along with non-linear and non-homogeneous, as well as post-yield properties of bone were taken into account in the FE models. The accuracy and precision of FE models in predicting bone strength were evaluated using statistical tests by comparing the FE results with the results obtained using In-Vitro Mechanical Tests on 14 cadaveric specimens and an independent data set. Results: According to paired t-test analysis, no significant difference was observed between the bone strengths predicted by FEM and those calculated by in-vitro tests. In addition, based on the results of regression analysis, there was a linear relationship between and with a slope not different from 1. Discussion: The obtained results show the capability of QCT-based FEM in predicting bone strength in distal femur following GCT surgery, and thus they can be employed to investigate various features of the bone-cement construct with the hope of shedding light on the obscure aspects of the problem.

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APA: Copy

Rouhi, Gholamreza, GHOUCHANI, AZADEH, & EBRAHIMZADEH, MOHAMAD HOSEIN. (2018). Prediction of mechanical strength of distal femur following GCT surgery using quantitative computed tomography based finite element method. IRANIAN JOURNAL OF ORTHOPAEDIC SURGERY, 16(3 (62) ), 243-250. SID. https://sid.ir/paper/85354/en

Vancouver: Copy

Rouhi Gholamreza, GHOUCHANI AZADEH, EBRAHIMZADEH MOHAMAD HOSEIN. Prediction of mechanical strength of distal femur following GCT surgery using quantitative computed tomography based finite element method. IRANIAN JOURNAL OF ORTHOPAEDIC SURGERY[Internet]. 2018;16(3 (62) ):243-250. Available from: https://sid.ir/paper/85354/en

IEEE: Copy

Gholamreza Rouhi, AZADEH GHOUCHANI, and MOHAMAD HOSEIN EBRAHIMZADEH, “Prediction of mechanical strength of distal femur following GCT surgery using quantitative computed tomography based finite element method,” IRANIAN JOURNAL OF ORTHOPAEDIC SURGERY, vol. 16, no. 3 (62) , pp. 243–250, 2018, [Online]. Available: https://sid.ir/paper/85354/en

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