DIFFERENT DOSES OF FURAZOLIDONE (FUR) WITH AMOXICILLIN (AMOX) AND OMEPRAZOLE (OM) ON ERADICATION OF M.PYLORI INFECTION: A RANDOMIZED CONTROLLED STUDY

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SALMAN ROUGHANI HASAN; SHIREKHODA M.; BUTORABI Z.

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Journal: GOVARESH JOURNAL Year:2002 | Volume:7 | Issue:37-38 Page(s): 27-32

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Title

DIFFERENT DOSES OF FURAZOLIDONE (FUR) WITH AMOXICILLIN (AMOX) AND OMEPRAZOLE (OM) ON ERADICATION OF M.PYLORI INFECTION: A RANDOMIZED CONTROLLED STUDY

Author(s)

SALMAN ROUGHANI HASAN | SHIREKHODA M. | BUTORABI Z. | Issue Writer Certificate

Keywords

ERADICATIONQ3

H.PYLORIQ3

FURAZOLIDONEQ4

Abstract

Background: Resistance to metronidazole is one of the most common reason for treatment failure with classic triple therapy. On the other hand clarithromycine is not cost effective for developing countries and resistance to it is increasing. FUR is a very good substitute for these antibiotics with regard to efficacy, lack of resistance and low price (Alim. Pharmacol. Ther. 2000:14; 299, 2001; 15:411), but its high side effects limit its use. The aim of the study was to assess the efficacy of two different dose of FUR in combination with AMOX and OM for H.PYLORI ERADICATION.Material and method: A total of 123 patients with duodenal ulcer, were randomized and received the following medications for two weeks. Group A: FUR 2x200 mg + AMOX 2x1gr + OM 2x20 mg/day. Group B: FUR 2x50 mg+ AMOX 2x1gr + OM 2x20 mg/day. Control endoscopy was performed after 6 weeks and two biopsy specimens from antrum and two from corpus were taken for a urease test and histology. ERADICATION was concluded if all two tests were negative for H.PYLORI.Results: In total, 110 patients completed the study .4patients in group A did not tolerate the regimen on day 8 of therapy and were excluded from the study. Serious complication such as fever, fatigue and dizziness, which occurred in the beginning of second week of treatment (day 8 to 10), were common in group A than group B (19% and 15.9% in A versus 0% in B) The ERADICATION rate by per protocol analysis was significantly higher in A than B (88.9% versus 67.9% respectively, p=0.008). However it was low and not statistically significant, by intention to treat analysis (76.2% in A and 62.3% in B, p=0.09).Conclusion: The regimen with non-reduced dose of Fur in combination with Amox and Om was effective, when the patients tolerated the drugs and completed the study.

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APA: Copy

SALMAN ROUGHANI, HASAN, SHIREKHODA, M., & BUTORABI, Z.. (2002). DIFFERENT DOSES OF FURAZOLIDONE (FUR) WITH AMOXICILLIN (AMOX) AND OMEPRAZOLE (OM) ON ERADICATION OF M.PYLORI INFECTION: A RANDOMIZED CONTROLLED STUDY. GOVARESH JOURNAL, 7(37-38), 27-32. SID. https://sid.ir/paper/86074/en

Vancouver: Copy

SALMAN ROUGHANI HASAN, SHIREKHODA M., BUTORABI Z.. DIFFERENT DOSES OF FURAZOLIDONE (FUR) WITH AMOXICILLIN (AMOX) AND OMEPRAZOLE (OM) ON ERADICATION OF M.PYLORI INFECTION: A RANDOMIZED CONTROLLED STUDY. GOVARESH JOURNAL[Internet]. 2002;7(37-38):27-32. Available from: https://sid.ir/paper/86074/en

IEEE: Copy

HASAN SALMAN ROUGHANI, M. SHIREKHODA, and Z. BUTORABI, “DIFFERENT DOSES OF FURAZOLIDONE (FUR) WITH AMOXICILLIN (AMOX) AND OMEPRAZOLE (OM) ON ERADICATION OF M.PYLORI INFECTION: A RANDOMIZED CONTROLLED STUDY,” GOVARESH JOURNAL, vol. 7, no. 37-38, pp. 27–32, 2002, [Online]. Available: https://sid.ir/paper/86074/en

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