CYCLOSPORINE THERAPY FOR AUTOIMMUNE HEPATITIS IN CHILDREN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

IRANIKHAH A.; NAJAFI SANI M.; KHODADAD A.; SANEIAN H.; MIR NASSERI M.H.; AGHAALI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: GOVARESH JOURNAL Year:2011 | Volume:15 | Issue:4 (73) Page(s): 254-262

Download Full-Text

Persian Verion

View:

2,142

Download:

Cites:

Information Journal Paper

Title

CYCLOSPORINE THERAPY FOR AUTOIMMUNE HEPATITIS IN CHILDREN

Author(s)

Keywords

AUTOIMMUNE HEPATITISQ4

CYCLOSPORINEQ3

TREATMENTQ3

CHILDRENQ3

IRANQ2

Abstract

Background: The current immunosuppressive TREATMENT of patients with AUTOIMMUNE HEPATITIS (AIH) consists of prednisolone and azathioprine. High doses of prednisolone used for disease remission are not universally effective and have serious adverse effects. Some authors have provided evidence of AIH therapy in CHILDREN and adults with CYCLOSPORINE (Neoral) should corticosteroid therapy become ineffective. Preliminary results using CYCLOSPORINE in a small group of patients have shown that this drug appears to be a good substitute for corticosteroids. We performed this study to assess the efficacy and safety of CYCLOSPORINE in induction of remission in CHILDREN with AIH.Methods: This was a case series, interventional clinical trial that involved CHILDREN with AIH. twelve CHILDREN with a median age of 9 years, 3 months who were diagnosed according to international criteria as having definite AIH were recruited. CYCLOSPORINE alone was administered at a dosage of 3.5-5 mg/kg in 3 daily doses for 5 months, followed by low dose prednisolone (0.3 mg/kg/d) for one month, then followed by combined low doses of prednisolone and azathioprine (1.5 mg/kg/d in two doses). Patients discontinued CYCLOSPORINE after seven months. Biochemical remission of the disease was established by assessment of serum transaminase activity levels. Growth parameters that included Z-scores for height and weight, and adverse effects of the TREATMENT were recorded.Results: Of the 10 remaining patients, 7 had normalized alanine aminotransferase (ALT) activity levels by 4 months and all patients had normalized ALT levels by 9 months of TREATMENT. Adverse effects of CYCLOSPORINE were mild and disappeared during weaning off the medication.Conclusion: CYCLOSPORINE induced biochemical remission of the hepatic inflammatory/necrotic process in CHILDREN with AIH.There were few, well–tolerated adverse effects. Longer follow-up of patients is necessary to establish possible long-term toxicity of CYCLOSPORINE.

Cites

No record.

References

No record.

Cite

APA: Copy

IRANIKHAH, A., NAJAFI SANI, M., KHODADAD, A., SANEIAN, H., MIR NASSERI, M.H., & AGHAALI, M.. (2011). CYCLOSPORINE THERAPY FOR AUTOIMMUNE HEPATITIS IN CHILDREN. GOVARESH JOURNAL, 15(4 (73)), 254-262. SID. https://sid.ir/paper/86163/en

Vancouver: Copy

IRANIKHAH A., NAJAFI SANI M., KHODADAD A., SANEIAN H., MIR NASSERI M.H., AGHAALI M.. CYCLOSPORINE THERAPY FOR AUTOIMMUNE HEPATITIS IN CHILDREN. GOVARESH JOURNAL[Internet]. 2011;15(4 (73)):254-262. Available from: https://sid.ir/paper/86163/en

IEEE: Copy

A. IRANIKHAH, M. NAJAFI SANI, A. KHODADAD, H. SANEIAN, M.H. MIR NASSERI, and M. AGHAALI, “CYCLOSPORINE THERAPY FOR AUTOIMMUNE HEPATITIS IN CHILDREN,” GOVARESH JOURNAL, vol. 15, no. 4 (73), pp. 254–262, 2011, [Online]. Available: https://sid.ir/paper/86163/en

Related Journal Papers