EVALUATION OF THE EFFICACY OF INTRA-NASAL MIDAZOLAM FOR SEDATION DURING UPPER ENDOSCOPY: A RANDOMIZED CLINICAL PILOT STUDY

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KADKHODAEE AHMAD; HAJIANI ESKANDAR; MASJEDIZADEH ABDOLRAHIM; SHAYESTEH ALI AKBAR; ALAVI NEJAD PEZHMAN; HASHEMI SEID JALAL; SEBGHATOLLAHI VAHID

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Journal: GOVARESH JOURNAL Year:2013 | Volume:18 | Issue:1 (82) Page(s): 28-31

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Title

EVALUATION OF THE EFFICACY OF INTRA-NASAL MIDAZOLAM FOR SEDATION DURING UPPER ENDOSCOPY: A RANDOMIZED CLINICAL PILOT STUDY

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Keywords

MIDAZOLAMQ3

UPPER ENDOSCOPYQ2

SEDATIONQ3

Abstract

Background: UPPER ENDOSCOPY, as an important diagnostic and occasional therapeutic tool is invasive. SEDATION of patients during the endoscopy procedure with minimal side effects could raise patient tolerability, allowing for ease and increased effectiveness of this procedure.Materials and Methods: In this study, 105 patients who were candidates for the UPPER ENDOSCOPY procedure were randomly divided into two groups: (A) MIDAZOLAM (n=53) and (B) placebo (n=52). Group A patients received 5 mg of MIDAZOLAM dissolved in 5 cc distilled water and group B received 5 cc of distilled water, via an intra-nasal drip. After 40 to 45 minutes, the UPPER ENDOSCOPY was performed. During the endoscopy, patients were monitored and the endoscopy time, gag reflex stimulation, heart rate, arterial oxygen saturation (SPO2), amnesia and patient justification were recorded and compared.Results: The average age in group A was 39.3 years; for group B, it was 39.9 years. There were no statistically significant results for average endoscopy time (p=0.23), gag reflex stimulation (p=0.27), heart rate (p=0.09), SPO2 (p=0.49), amnesia (p=0.12), and patient justification (p=0.1) between both groups.Conclusion: According to the results of this study, it seems that intra-nasal MIDAZOLAM is not effective for patient SEDATION. This field needs additional evaluation.

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APA: Copy

KADKHODAEE, AHMAD, HAJIANI, ESKANDAR, MASJEDIZADEH, ABDOLRAHIM, SHAYESTEH, ALI AKBAR, ALAVI NEJAD, PEZHMAN, HASHEMI, SEID JALAL, & SEBGHATOLLAHI, VAHID. (2013). EVALUATION OF THE EFFICACY OF INTRA-NASAL MIDAZOLAM FOR SEDATION DURING UPPER ENDOSCOPY: A RANDOMIZED CLINICAL PILOT STUDY. GOVARESH JOURNAL, 18(1 (82)), 28-31. SID. https://sid.ir/paper/86179/en

Vancouver: Copy

KADKHODAEE AHMAD, HAJIANI ESKANDAR, MASJEDIZADEH ABDOLRAHIM, SHAYESTEH ALI AKBAR, ALAVI NEJAD PEZHMAN, HASHEMI SEID JALAL, SEBGHATOLLAHI VAHID. EVALUATION OF THE EFFICACY OF INTRA-NASAL MIDAZOLAM FOR SEDATION DURING UPPER ENDOSCOPY: A RANDOMIZED CLINICAL PILOT STUDY. GOVARESH JOURNAL[Internet]. 2013;18(1 (82)):28-31. Available from: https://sid.ir/paper/86179/en

IEEE: Copy

AHMAD KADKHODAEE, ESKANDAR HAJIANI, ABDOLRAHIM MASJEDIZADEH, ALI AKBAR SHAYESTEH, PEZHMAN ALAVI NEJAD, SEID JALAL HASHEMI, and VAHID SEBGHATOLLAHI, “EVALUATION OF THE EFFICACY OF INTRA-NASAL MIDAZOLAM FOR SEDATION DURING UPPER ENDOSCOPY: A RANDOMIZED CLINICAL PILOT STUDY,” GOVARESH JOURNAL, vol. 18, no. 1 (82), pp. 28–31, 2013, [Online]. Available: https://sid.ir/paper/86179/en

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