REFRACTORY CELIAC DISEASE; DIAGNOSIS, TREATMENT AND CLINICAL MANIFESTATIONS

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SADEGHI AMIR; EHSANI ARDAKANI MOHAMMAD JAVAD; JAMSHIDFAR NEGYN; ROSTAMI NEJAD MOHAMMAD; ZALI MOHAMMAD REZA

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Journal: GOVARESH JOURNAL Year:2017 | Volume:22 | Issue:1 Page(s): 7-15

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Title

REFRACTORY CELIAC DISEASE; DIAGNOSIS, TREATMENT AND CLINICAL MANIFESTATIONS

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Keywords

REFRACTORY CELIAC DISEASEQ1

TREATMENTQ3

DIAGNOSISQ3

CLINICAL MANIFESTATIONQ3

Abstract

Celiac disease as an autoimmune disease is predisposes in genetically susceptible subjects due to theconsumption of wheat and other grains containing gluten and as a result of immunological responses,villous atrophy, mucosal hyperplasia, and lymphocytic infiltration will be occurred. The only TREATMENT isa lifelong gluten-free diet. Most patients with celiac disease respond to gluten-free diet (GFD). But in asmall percentage of patients, despite full compliance with gluten-free diet, symptoms and mucosal atrophyare remains. When other causes of mucosal atrophy are rejected, the DIAGNOSIS of REFRACTORY CELIAC DISEASE(RCD) is suggested. Based on the abnormality in population of intraepithelial lymphocytes (IEL), RCDis divided into two types 1; (RCD I) and type 2 (RCDII). Prognosis, clinical symptoms and endoscopicfindings of RCD I are better and milder than the RCD II. TREATMENT of RCD I is based on immunosuppressivetherapy and RCD II is mostly based on nutritional support and chemotherapeutic agents. In this review theclinical characteristics, diagnostic and TREATMENT approach of RCD will be reviewed.

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APA: Copy

SADEGHI, AMIR, EHSANI ARDAKANI, MOHAMMAD JAVAD, JAMSHIDFAR, NEGYN, ROSTAMI NEJAD, MOHAMMAD, & ZALI, MOHAMMAD REZA. (2017). REFRACTORY CELIAC DISEASE; DIAGNOSIS, TREATMENT AND CLINICAL MANIFESTATIONS. GOVARESH JOURNAL, 22(1 ), 7-15. SID. https://sid.ir/paper/86210/en

Vancouver: Copy

SADEGHI AMIR, EHSANI ARDAKANI MOHAMMAD JAVAD, JAMSHIDFAR NEGYN, ROSTAMI NEJAD MOHAMMAD, ZALI MOHAMMAD REZA. REFRACTORY CELIAC DISEASE; DIAGNOSIS, TREATMENT AND CLINICAL MANIFESTATIONS. GOVARESH JOURNAL[Internet]. 2017;22(1 ):7-15. Available from: https://sid.ir/paper/86210/en

IEEE: Copy

AMIR SADEGHI, MOHAMMAD JAVAD EHSANI ARDAKANI, NEGYN JAMSHIDFAR, MOHAMMAD ROSTAMI NEJAD, and MOHAMMAD REZA ZALI, “REFRACTORY CELIAC DISEASE; DIAGNOSIS, TREATMENT AND CLINICAL MANIFESTATIONS,” GOVARESH JOURNAL, vol. 22, no. 1 , pp. 7–15, 2017, [Online]. Available: https://sid.ir/paper/86210/en

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