AZITHROMYCIN IN ONE WEEK QUADRUPLE THERAPY FOR H. PYLORI ERADICATION

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MOUSAVI SHAHROKH; TOUSI J.; ZAHMATKESH M.; NANVABASHI F.

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Paper Information

Journal: GOVARESH JOURNAL Year:2005 | Volume:10 | Issue:3 (SN 52) Page(s): 140-145

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Information Journal Paper

Title

AZITHROMYCIN IN ONE WEEK QUADRUPLE THERAPY FOR H. PYLORI ERADICATION

Author(s)

MOUSAVI SHAHROKH | TOUSI J. | ZAHMATKESH M. | NANVABASHI F. | Issue Writer Certificate

Keywords

AZITHROMYCINQ3

HELICOBACTER PYLORIQ3

PEPTIC ULCERQ3

TREATMENTQ3

Abstract

Background: In developing countries primary antibiotic-resistance and poor compliance are the main causes of HELICOBACTER PYLORI (HP) eradication failure of standard regimens. AIM: To investigate eradication rate, patient's compliance and tolerability of a 1-wk AZITHROMYCIN based quaruple therapy versus the 2-wk conventional therapy.Materials and Methods: A total of 129 HP-positive patients were randomized to either omeprazole 20mg, bismuth subcitrate 240 mg, AZITHROMYCIN 250 mg, metronidazole 500 mg, all twice daily for 1- wk (BOAzM) or omeprazole 20mg, bismuth subcitrate 240 mg, amoxicillin 1g, metronidazole 500 mg all twice daily for 2-wk (B-OAM). HP infection was defined at entry by histology and rapid urease test and cure of infection was determined by negative urea breath test.Results: HP eradication rates of B-OAzM and B-OAM were74.1% and 70.4% respectively at intention to treat and per-protocol analysis 78.1%versus 75.7% respectively. incidence of poor compliance was lower, although not significant, in patients randomized to B-OAzM than for B-OAM (3.5% versus 4.3 %) but intolerability was similar in two groups ( 35% versus 33.3% ). Conclusions: 1-wk AZITHROMYCIN based quadruple regimen achieves an HP eradication rate comparable to that of standard 2-wk quadruple Therapy and is associated with same patient's compliance and complications.

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APA: Copy

MOUSAVI, SHAHROKH, TOUSI, J., ZAHMATKESH, M., & NANVABASHI, F.. (2005). AZITHROMYCIN IN ONE WEEK QUADRUPLE THERAPY FOR H. PYLORI ERADICATION. GOVARESH JOURNAL, 10(3 (SN 52)), 140-145. SID. https://sid.ir/paper/86308/en

Vancouver: Copy

MOUSAVI SHAHROKH, TOUSI J., ZAHMATKESH M., NANVABASHI F.. AZITHROMYCIN IN ONE WEEK QUADRUPLE THERAPY FOR H. PYLORI ERADICATION. GOVARESH JOURNAL[Internet]. 2005;10(3 (SN 52)):140-145. Available from: https://sid.ir/paper/86308/en

IEEE: Copy

SHAHROKH MOUSAVI, J. TOUSI, M. ZAHMATKESH, and F. NANVABASHI, “AZITHROMYCIN IN ONE WEEK QUADRUPLE THERAPY FOR H. PYLORI ERADICATION,” GOVARESH JOURNAL, vol. 10, no. 3 (SN 52), pp. 140–145, 2005, [Online]. Available: https://sid.ir/paper/86308/en

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